肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
Cancer Research and Clinic
2015年
9期
640-642
,共3页
牛海静(综述)%苏秉忠(审校)
牛海靜(綜述)%囌秉忠(審校)
우해정(종술)%소병충(심교)
胃黏膜肠化生%表型转变%机制
胃黏膜腸化生%錶型轉變%機製
위점막장화생%표형전변%궤제
Gastric intestinal metaplasia%Phenotype shift%Pathogenesis
胃黏膜肠化生是临床常见的病理学诊断，是肠型胃癌的癌前病变，其发病机制目前还不清楚，主要与幽门螺杆菌（Hp）感染、胆汁反流、亚硝酸盐的摄入及维生素缺乏等有关。研究发现，胃上皮向肠上皮转分化所涉及的相关基因有CDX2、SOX2、PDX1、OCT1、SHH、Runx3、Tff等。总之，胃黏膜肠化生表型转变是一个复杂且漫长的过程，目前针对其病因如Hp感染、胆汁反流等的治疗仅能控制其进展而未能反转其临床过程，仍需深入探明其发病机制，以指导临床治疗。
胃黏膜腸化生是臨床常見的病理學診斷，是腸型胃癌的癌前病變，其髮病機製目前還不清楚，主要與幽門螺桿菌（Hp）感染、膽汁反流、亞硝痠鹽的攝入及維生素缺乏等有關。研究髮現，胃上皮嚮腸上皮轉分化所涉及的相關基因有CDX2、SOX2、PDX1、OCT1、SHH、Runx3、Tff等。總之，胃黏膜腸化生錶型轉變是一箇複雜且漫長的過程，目前針對其病因如Hp感染、膽汁反流等的治療僅能控製其進展而未能反轉其臨床過程，仍需深入探明其髮病機製，以指導臨床治療。
위점막장화생시림상상견적병이학진단，시장형위암적암전병변，기발병궤제목전환불청초，주요여유문라간균（Hp）감염、담즙반류、아초산염적섭입급유생소결핍등유관。연구발현，위상피향장상피전분화소섭급적상관기인유CDX2、SOX2、PDX1、OCT1、SHH、Runx3、Tff등。총지，위점막장화생표형전변시일개복잡차만장적과정，목전침대기병인여Hp감염、담즙반류등적치료부능공제기진전이미능반전기림상과정，잉수심입탐명기발병궤제，이지도림상치료。
Gastric intestinal metaplasia (IM), a common clinical pathological diagnosis, is a premalignant condition of intestinal type gastric cancer. The pathogenesis is still unclear, which links with helicobacter pylori (Hp) infection, bile reflux, nitrite intake, vitamin deficiency and so on. In recent studies, the relevant genes involved with transdifferentiation of gastric epithelium to intestinal epithelium are CDX2, SOX2, PDX1, OCT1, SHH, Runx3, Tff, and so on. Overall, the phenotype shift of gastric intestinal metaplasia is a complex and long process, current treatments targeted to the cause of IM such as Hp infection, bile reflux only can prevent its development, but fail to reverse the clinical process, so further clarification to the pathogenesis is still needed to guide the clinical treatment.
