肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
Cancer Research and Clinic
2015年
9期
627-629
,共3页
食管肿瘤%放射疗法%鸦胆子油口服乳液
食管腫瘤%放射療法%鴉膽子油口服乳液
식관종류%방사요법%아담자유구복유액
Esophageal neoplasms%Radiotherapy%Brucea javanica oil emulsion
目的：探讨鸦胆子油口服乳液联合放疗治疗食管癌的疗效及患者不良反应。方法选取初治食管鳞状细胞癌患者50例，按随机数字表法分为观察组和对照组，各25例。所有患者均给予三维适形调强放疗，处方剂量95%计划靶区64 Gy，32次分割。观察组放疗同时给予鸦胆子油口服乳液，对照组仅单纯放疗。比较两组患者疗效、放疗反应及生活质量改善情况。结果观察组治疗有效率为92%（23／25），对照组为68%（17／25），两组差异有统计学意义（χ2＝4.500，P＝0.034）。观察组2级及以上放射性食管炎的发生率为20%（5／25），对照组为60%（15／25），两组差异有统计学意义（χ2＝8.333，P＝0.004）。观察组生命质量改善率为68%（17／25），对照组为40%（10／25），两组差异有统计学意义（χ2＝3.945，P＝0.047）。结论放疗联合鸦胆子油口服乳液治疗食管癌可提高疗效，减轻放疗反应，提高患者生命质量。
目的：探討鴉膽子油口服乳液聯閤放療治療食管癌的療效及患者不良反應。方法選取初治食管鱗狀細胞癌患者50例，按隨機數字錶法分為觀察組和對照組，各25例。所有患者均給予三維適形調彊放療，處方劑量95%計劃靶區64 Gy，32次分割。觀察組放療同時給予鴉膽子油口服乳液，對照組僅單純放療。比較兩組患者療效、放療反應及生活質量改善情況。結果觀察組治療有效率為92%（23／25），對照組為68%（17／25），兩組差異有統計學意義（χ2＝4.500，P＝0.034）。觀察組2級及以上放射性食管炎的髮生率為20%（5／25），對照組為60%（15／25），兩組差異有統計學意義（χ2＝8.333，P＝0.004）。觀察組生命質量改善率為68%（17／25），對照組為40%（10／25），兩組差異有統計學意義（χ2＝3.945，P＝0.047）。結論放療聯閤鴉膽子油口服乳液治療食管癌可提高療效，減輕放療反應，提高患者生命質量。
목적：탐토아담자유구복유액연합방료치료식관암적료효급환자불량반응。방법선취초치식관린상세포암환자50례，안수궤수자표법분위관찰조화대조조，각25례。소유환자균급여삼유괄형조강방료，처방제량95%계화파구64 Gy，32차분할。관찰조방료동시급여아담자유구복유액，대조조부단순방료。비교량조환자료효、방료반응급생활질량개선정황。결과관찰조치료유효솔위92%（23／25），대조조위68%（17／25），량조차이유통계학의의（χ2＝4.500，P＝0.034）。관찰조2급급이상방사성식관염적발생솔위20%（5／25），대조조위60%（15／25），량조차이유통계학의의（χ2＝8.333，P＝0.004）。관찰조생명질량개선솔위68%（17／25），대조조위40%（10／25），량조차이유통계학의의（χ2＝3.945，P＝0.047）。결론방료연합아담자유구복유액치료식관암가제고료효，감경방료반응，제고환자생명질량。
Objective To evaluate the efficacy and untoward effects of brucea javanica oil emulsion combined with radiotherapy in the treatment of patients with esophageal cancer. Methods 50 initial treatment patients with esophageal squamous cell carcinoma were randomly assigned to observation group (25 cases) and control group (25 cases). All patients were treated with three dimensional conformal intensity modulated radiation therapy (3D-IMRT) and the radiation dose was 64 Gy/32 times (95 % PTV). The patients in observation group received the treatment of brucea javanica oil emulsion during radiotherapy. The differences between the two groups were compared in respect of the efficacy, the adverse reactions and the quality of life (QOL). Results The effective rate in observation group was 92%(23/25) and it was 68%(17/25) in control group, there was significant difference between the two groups (χ2 = 4.500, P= 0.034). The incidence of radiation esophagitis at the level of RTOG2 and above in observation group was 20%(5/25) and it was 60%(15/25) in the control group, there was significant difference between the two groups (χ2= 8.333, P=0.004). The improvement rate of QOL in observation group was 68 % (17/25) and it was 40 % (10/25) in control group, there was significant difference between the two groups (χ2 = 3.945, P= 0.047). Conclusion Brucea javanica oil emulsion combined with radiotherapy for the treatment of patients with esophageal cancer can improve the therapeutic effect and QOL,it can also reduce radiation reactions.
