CAJ | 학술논문

[目的]总结自体干细胞移植治疗晚期肝硬化病人的疗效及围术期护理。[方法]对100例内科保守治疗无效的晚期肝硬化病人采用自体外周血干细胞移植,术前采取针对性心理干预,做好术后康复指导,观察药物不良反应,术后严密观察生命体征变化,预防并发症发生。随访1年后观察病人一般情况及肝功能情况。[结果]100例病人术后1年存活率100%,其中52例大量腹水病人术后腹水逐渐减少直到消失,4例术后3个月出现上消化道出血,3例出现Ⅰ度~Ⅱ度肝性脑病。移植术后6个月、12个月肝脏合成功能、肝脏储备功能、肝弹性测定均有显著改善,与移植前相比差异有统计学意义(P <0.05)。[结论]自体外周血干细胞移植可以有效地改善晚期肝硬化病人的肝脏功能、肝组织形态学,提高病人的生活质量,围术期护理可促进病人康复,提高治疗效果。
[목적]총결자체간세포이식치료만기간경화병인적료효급위술기호리。[방법]대100례내과보수치료무효적만기간경화병인채용자체외주혈간세포이식,술전채취침대성심리간예,주호술후강복지도,관찰약물불량반응,술후엄밀관찰생명체정변화,예방병발증발생。수방1년후관찰병인일반정황급간공능정황。[결과]100례병인술후1년존활솔100%,기중52례대량복수병인술후복수축점감소직도소실,4례술후3개월출현상소화도출혈,3례출현Ⅰ도~Ⅱ도간성뇌병。이식술후6개월、12개월간장합성공능、간장저비공능、간탄성측정균유현저개선,여이식전상비차이유통계학의의(P <0.05)。[결론]자체외주혈간세포이식가이유효지개선만기간경화병인적간장공능、간조직형태학,제고병인적생활질량,위술기호리가촉진병인강복,제고치료효과。
Objective:To summarize the curative effect and perioperative care of advanced cirrhosis patients trea-ted with autologous stem cells transplantation.Methods:A total of 100 advanced cirrhosis patients who had fail-ure conservative therapy by internal medicine were conducted with autologous peripheral blood stem cells trans-plantation for advanced cirrhosis.Preoperative targeted psychological intervention,targeted psychological inter-vention was taken for them,and postoperative rehabilitation guidance was did well,the drug adverse reactions were observed,the vital signs were observed closely and to prevent the complications.Results:One year surviv-al rate was 100% in 100 patients ,the ascites was gradually reduced and disappeared in 52 patients with massive ascites.4 patients underwent upper gastrointestinal bleeding at postoperative 3 months and 3 patients developed with Ⅰ Ⅱ degree of hepatic encephalopathy.After transplantation,the liver synthetic function,liver reserve function and liver elasticity determination were significantly improved (P <0.05 )compared with that before transplantation.Conclusion:Autologous peripheral blood stem cells transplantation could improve the liver func-tion and liver tissue morphology of advanced cirrhosis patients and their quality of life.Perioperative holistic nursing can promote the rehabilitation of patients and improve the curative effect.