CAJ | 학술논문

目的: 研究黄芪联合应用阿托伐他汀对兔急性心肌梗死 ( AMI) 后梗死边缘区及非梗死区心肌细胞瞬间外向钾电流 ( Ito ) 的影响. 方法: 建立AMI动物模型后, 分别通过口服阿托伐他汀、腹腔注射黄芪注射液, 酶解分离心室肌细胞, 采用全细胞膜片钳记录技术记录梗死边缘区及非梗死区心外膜心肌细胞 ( Epicardium, Epi) Ito密度. 结果: AMI梗死边缘区及非梗死区Epi细胞Ito密度与正常心肌细胞相比存在差异性; 阿托伐他汀和黄芪分别使受抑制的梗死边缘区及非梗死区Ito密度恢复; 阿托伐他汀和黄芪联合应用使梗死边缘区及非梗死区Ito密度进一步恢复. 结论: AMI后梗死边缘区及非梗死区Epi细胞Ito密度存在电生理异常; 阿托伐他汀和黄芪对心肌梗死梗死边缘区及非梗死区Ito密度的电生理异常有部分改善作用.
목적: 연구황기연합응용아탁벌타정대토급성심기경사 ( AMI) 후경사변연구급비경사구심기세포순간외향갑전류 ( Ito ) 적영향. 방법: 건립AMI동물모형후, 분별통과구복아탁벌타정、 복강주사황기주사액, 매해분리심실기세포, 채용전세포막편겸기록기술기록경사변연구급비경사구심외막심기세포 ( Epicardium, Epi) Ito밀도. 결과: AMI경사변연구급비경사구Epi세포Ito밀도여정상심기세포상비존재차이성; 아탁벌타정화황기분별사수억제적경사변연구급비경사구Ito밀도회복; 아탁벌타정화황기연합응용사경사변연구급비경사구Ito밀도진일보회복. 결론: AMI후경사변연구급비경사구Epi세포Ito밀도존재전생리이상; 아탁벌타정화황기대심기경사경사변연구급비경사구Ito밀도적전생리이상유부분개선작용.
Objective:to study the effect of Huangqi combined with Atorvastatin on moment outward potassium current Ito on epi-cardium of infarction marginal zone and non-infarction zone in rabbits with AMI. Methods:AMI animal models prepared, Ito density of Epi was recorded with patch clamp technique by taking orally atorvastatin, getting intraperitoneal injection with Huangqi, separating ventricular myocardium through enzymolysis. Results: there was difference between Ito densities of Epi of infarction zone and normal Epi;Atorvastatin and Huangqi could respectively restore the Ito density of Epi of both zones;the combination could further restore the density. Conclusion:Ito density of Epi of post-AMI infarction marginal zone and none-infarction zone has electrophysiological abnormali-ty;Atorvastatin and Huangqi can improve the abnormality to a certain degree.