中国临床药理学杂志
中國臨床藥理學雜誌
중국림상약이학잡지
The Chinese Journal of Clinical Pharmacology
2015年
18期
1803-1805
,共3页
社区获得性肺炎%老年患者%莫西沙星%左氧氟沙星%临床疗效%安全性
社區穫得性肺炎%老年患者%莫西沙星%左氧氟沙星%臨床療效%安全性
사구획득성폐염%노년환자%막서사성%좌양불사성%림상료효%안전성
community acquired pneumonia%elderly patients%moxifloxacin%levofloxacin%clinical efficacy%safety
目的：评价莫西沙星与左氧氟沙星治疗老年社区获得性肺炎的临床疗效及安全性。方法将62例老年社区获得性肺炎患者随机分为试验组32例和对照组30例。试验组予以静脉输注莫西沙星400 mg，qd，待患者症状好转后，改为口服莫西沙星片400 mg，qd，总疗程不超过2周；对照组予以静脉输注左氧氟沙星500 mg，qd，待症状好转后，改为口服左氧氟沙星片100 mg，tid，总疗程不超过2周。比较2组患者的临床疗效、用药时间、致病菌清除率及不良反应发生率。结果治疗结束后，试验组总有效率为93.75％，对照组为83.33％（ P>0.05），但试验组治愈率显著高于对照组（ P＜0.05）。试验组用药时间明显短于对照组（ P ＜0.05）。试验组致病菌清除率94.12％显著高于对照组66.67％（ P＜0.05）。2组患者药物相关不良反应发生率比较差异无统计学意义（ P>0.05）。结论莫西沙星与左氧氟沙星治疗老年社区获得性肺炎是安全有效的，试验组致病菌清除率较高。
目的：評價莫西沙星與左氧氟沙星治療老年社區穫得性肺炎的臨床療效及安全性。方法將62例老年社區穫得性肺炎患者隨機分為試驗組32例和對照組30例。試驗組予以靜脈輸註莫西沙星400 mg，qd，待患者癥狀好轉後，改為口服莫西沙星片400 mg，qd，總療程不超過2週；對照組予以靜脈輸註左氧氟沙星500 mg，qd，待癥狀好轉後，改為口服左氧氟沙星片100 mg，tid，總療程不超過2週。比較2組患者的臨床療效、用藥時間、緻病菌清除率及不良反應髮生率。結果治療結束後，試驗組總有效率為93.75％，對照組為83.33％（ P>0.05），但試驗組治愈率顯著高于對照組（ P＜0.05）。試驗組用藥時間明顯短于對照組（ P ＜0.05）。試驗組緻病菌清除率94.12％顯著高于對照組66.67％（ P＜0.05）。2組患者藥物相關不良反應髮生率比較差異無統計學意義（ P>0.05）。結論莫西沙星與左氧氟沙星治療老年社區穫得性肺炎是安全有效的，試驗組緻病菌清除率較高。
목적：평개막서사성여좌양불사성치료노년사구획득성폐염적림상료효급안전성。방법장62례노년사구획득성폐염환자수궤분위시험조32례화대조조30례。시험조여이정맥수주막서사성400 mg，qd，대환자증상호전후，개위구복막서사성편400 mg，qd，총료정불초과2주；대조조여이정맥수주좌양불사성500 mg，qd，대증상호전후，개위구복좌양불사성편100 mg，tid，총료정불초과2주。비교2조환자적림상료효、용약시간、치병균청제솔급불량반응발생솔。결과치료결속후，시험조총유효솔위93.75％，대조조위83.33％（ P>0.05），단시험조치유솔현저고우대조조（ P＜0.05）。시험조용약시간명현단우대조조（ P ＜0.05）。시험조치병균청제솔94.12％현저고우대조조66.67％（ P＜0.05）。2조환자약물상관불량반응발생솔비교차이무통계학의의（ P>0.05）。결론막서사성여좌양불사성치료노년사구획득성폐염시안전유효적，시험조치병균청제솔교고。
Objective To explore the clinical efficacy and safety analy-sis of moxifloxacin versus levofloxacin in the treatment of elderly patients with community acquired pneumonia ( CAP ) . Methods Sixty -two elderly patients with CAP were randomly divided into treatment group ( n=32 ) and control group ( n=30 ) .Patients in treatment group were treated with moxifloxacin 400 mg by intravenous transfusion , qd with changes for orally administration 400 mg qd after improvement.Patients in control group were treated with levofloxacin 500 mg by intravenous transfusion , qd with changes for orally administration 100 mg tid after improvement.The total course of administration was less than 2 weeks. The clinical efficacy , total course of administration , pathogenic bacteria clearance rate and safety were evaluated between the two groups . Results The total efficacy was not significant different between the two groups ( P>0.05 ) , but the cure rate in treatment group was significant higher than that in control group ( P<0.05 ) .The total course of drug administration of treatment group was shorter than control group (P<0.05).The pathogenic bacteria clearance rate was 93.75% and 83.33%for treatment and control group respectively which indicated that treatment group was significant higher ( P<0.05 ) .And the drug related <br> toxicity was not statistically different between the two groups ( P>0.05 ) .Conclusion Both moxifloxacin and levoflo-xacin were effective and safe in the treatment of elderly patients with community acquired pneumonia .And moxifloxacin had higher pathogenic bacteria clearance effects .
