中国药物警戒
中國藥物警戒
중국약물경계
Chinese Journal of Pharmacovigilance
2015年
9期
528-530
,共3页
氨溴索%法洛四联症%肺保护%疗效
氨溴索%法洛四聯癥%肺保護%療效
안추색%법락사련증%폐보호%료효
ambroxol%tetralogy of fallot%lung protection%efficacy
目的：探讨氨溴索在小儿法洛四联症术后的肺保护作用。方法收集2012年3月至2014年8月在本院行法洛四联症矫治术患儿62例，采用暗箱信封法，根据单双号将患者随机分为观察组（n=34）和对照组（n=34）。术毕，观察组予以氨溴索治疗；对照组患儿在相同时间给予等量生理盐水。观察两组患儿的ICU监护时间、机械通气时间、术后住院时间、术后1周内动脉血氧分压动态变化情况和治疗1周后动脉血氧分压、二氧化碳分压、氧合指数和肺部感染的发生情况。结果与对照组相比，观察组的ICU监护时间、机械通气时间、术后住院时间均具有显著差异（P<0.05）；与对照组相比，观察组患儿在术后第3、4 d动脉血氧分压变化具有显著性差异（P<0.05）；与对照组相比，观察组患儿在治疗1周后动脉血氧分压和氧合指数变化具有显著性差异（P<0.05）；住院期间，观察组患儿肺部感染率显著低于对照组（P<0.05）。结论氨溴索用于法洛四联症矫治术后肺部功能保护，能够改善患儿氧合功能，降低呼吸道并发症的发生，促进患儿术后康复，值得在临床中推广应用。
目的：探討氨溴索在小兒法洛四聯癥術後的肺保護作用。方法收集2012年3月至2014年8月在本院行法洛四聯癥矯治術患兒62例，採用暗箱信封法，根據單雙號將患者隨機分為觀察組（n=34）和對照組（n=34）。術畢，觀察組予以氨溴索治療；對照組患兒在相同時間給予等量生理鹽水。觀察兩組患兒的ICU鑑護時間、機械通氣時間、術後住院時間、術後1週內動脈血氧分壓動態變化情況和治療1週後動脈血氧分壓、二氧化碳分壓、氧閤指數和肺部感染的髮生情況。結果與對照組相比，觀察組的ICU鑑護時間、機械通氣時間、術後住院時間均具有顯著差異（P<0.05）；與對照組相比，觀察組患兒在術後第3、4 d動脈血氧分壓變化具有顯著性差異（P<0.05）；與對照組相比，觀察組患兒在治療1週後動脈血氧分壓和氧閤指數變化具有顯著性差異（P<0.05）；住院期間，觀察組患兒肺部感染率顯著低于對照組（P<0.05）。結論氨溴索用于法洛四聯癥矯治術後肺部功能保護，能夠改善患兒氧閤功能，降低呼吸道併髮癥的髮生，促進患兒術後康複，值得在臨床中推廣應用。
목적：탐토안추색재소인법락사련증술후적폐보호작용。방법수집2012년3월지2014년8월재본원행법락사련증교치술환인62례，채용암상신봉법，근거단쌍호장환자수궤분위관찰조（n=34）화대조조（n=34）。술필，관찰조여이안추색치료；대조조환인재상동시간급여등량생리염수。관찰량조환인적ICU감호시간、궤계통기시간、술후주원시간、술후1주내동맥혈양분압동태변화정황화치료1주후동맥혈양분압、이양화탄분압、양합지수화폐부감염적발생정황。결과여대조조상비，관찰조적ICU감호시간、궤계통기시간、술후주원시간균구유현저차이（P<0.05）；여대조조상비，관찰조환인재술후제3、4 d동맥혈양분압변화구유현저성차이（P<0.05）；여대조조상비，관찰조환인재치료1주후동맥혈양분압화양합지수변화구유현저성차이（P<0.05）；주원기간，관찰조환인폐부감염솔현저저우대조조（P<0.05）。결론안추색용우법락사련증교치술후폐부공능보호，능구개선환인양합공능，강저호흡도병발증적발생，촉진환인술후강복，치득재림상중추엄응용。
Objective To investigate the lung protective effects of ambroxol in children with tetralogy of fallot undergoing radical surgery. Methods From March 2012 to August 2014, a total of 61 children with tetralogy of fallot undergoing radical surgery were divided into normal observation group (n=34) and control group (n=34) randomly according to obscura envelope method. Ambroxol was applied in observation group at the end of operation, and normal saline was given in control group. The surgical case and breathing were recorded at each time point after operation. Results Compared with control group, the time of ICU, mechanical ventilation and hospitalization in observation group showed significant change after operation (P<0.05). Compared with control group, observation group showed signifi-cantly increased level of arterial partial pressure of oxygen on the third, fourth day after surgery (P<0.05). Com-pared with control group, observation group showed significant change of the arterial partial pressure of oxygen and oxygenation index in the first week after surgery (P<0.05). The incidence of infection in newborn in observation group showed obviously lower than those in the control group (P<0.05). Conclusion Ambroxol has a significant curative effect for lung protection in the patients after tetralogy of fallot surgery while avoiding respiratory complications, and it can be used widely in clinical work.
