CAJ | 학술논문

目的：比较生草乌、药典法制草乌、诃子制草乌的粉末和水煎液及诃子草乌配伍煎煮液7种样品急性毒性大小，探讨草乌炮制减毒原理。方法采用灌胃给药的方法，分别测定7种草乌样品对小鼠半数致死量（LD50）或最大给药量。结果生草乌粉末、诃子制草乌粉末、诃子草乌配伍煎液、诃子制草乌煎液、生草乌煎液的LD50分别为0.7009、1.1690、2.5600、4.0000、15.3200 g·kg-1；药典法制草乌粉末、药典法制草乌水煎液最大给药量分为20 g·kg-1和64 g·kg-1。结论生草乌毒性较大，生品经炮制或水煎煮后毒性均有不同程度降低。药典法制草乌无论粉末还是水煎液均无明显毒性。
목적：비교생초오、약전법제초오、가자제초오적분말화수전액급가자초오배오전자액7충양품급성독성대소，탐토초오포제감독원리。방법채용관위급약적방법，분별측정7충초오양품대소서반수치사량（LD50）혹최대급약량。결과생초오분말、가자제초오분말、가자초오배오전액、가자제초오전액、생초오전액적LD50분별위0.7009、1.1690、2.5600、4.0000、15.3200 g·kg-1；약전법제초오분말、약전법제초오수전액최대급약량분위20 g·kg-1화64 g·kg-1。결론생초오독성교대，생품경포제혹수전자후독성균유불동정도강저。약전법제초오무론분말환시수전액균무명현독성。
Objective To discuss the principle of the processing method of raw Aconiti kusnezoffii Radix by comparing the acute toxicity of seven kinds of samples made with Aconiti kusnezoffii Radix or its processed products. Methods The median lethal dose (LD50) or the maximum dose of seven kinds of samples were measured by gavage method on mice. Results The LD50 of powder of raw Aconiti kusnezoffii Radix, powder of Aconiti kusnezoffii Radix processed with Chebulae Fructus, decoction of compatibility of Aconiti kusnezoffii Radix and Chebulae Fructus, decoction of Aconiti kusnezoffii Radix processed with Chebulae Fructus, decoction of raw Aconiti kusnezoffii Radix decoction was respectively 0.7009, 1.1690, 2.5600, 4.0000, 15.3 200 g·kg-1. The MTD of powder and decoction of Aconiti kusnezoffii Radix processed by pharmacopoeia method was respectively 20 g·kg-1 and 64 g·kg-1. Conclusion Powder of raw Aconiti kusnezoffii Radix had obvious toxicity , the acute toxicity of raw Aconiti kusnezoffii Radix was reduced to varying degrees. Powder and decoction of Aconiti kusnezoffii Radix processed by pharmacopoeia method had no obvious toxicity.