中外医疗
中外醫療
중외의료
China Foreign Medical Treatment
2015年
25期
98-100
,共3页
脑卒中%诱导多功能干细胞%细胞治疗
腦卒中%誘導多功能榦細胞%細胞治療
뇌졸중%유도다공능간세포%세포치료
Stroke Induced%Pluripotent stem cells for%Cell therapy
目的：诱导多功能干细胞(induced pluripotent stem cells,IPSCs),方法主要是借助于诱导已分化的一种成熟体细胞异位,对某一个或者某一些基因进行表达,进而重新整编得到的一种多功能干细胞。结果诱导多功能干细胞和胚胎干细胞(embryonic stem cells,ESCs)有着一定的相似度,不仅仅存在高度增值性,同时也存在多向分化潜能,可以分化成为神经元。结论IPSCs具有无道德伦理障碍,无免疫排斥,取材方式简单、无创等优点,为脑卒中的细胞治疗提供了新的希望。现就近年来与iPSCs治疗脑卒中相关的研究作一综述。
目的：誘導多功能榦細胞(induced pluripotent stem cells,IPSCs),方法主要是藉助于誘導已分化的一種成熟體細胞異位,對某一箇或者某一些基因進行錶達,進而重新整編得到的一種多功能榦細胞。結果誘導多功能榦細胞和胚胎榦細胞(embryonic stem cells,ESCs)有著一定的相似度,不僅僅存在高度增值性,同時也存在多嚮分化潛能,可以分化成為神經元。結論IPSCs具有無道德倫理障礙,無免疫排斥,取材方式簡單、無創等優點,為腦卒中的細胞治療提供瞭新的希望。現就近年來與iPSCs治療腦卒中相關的研究作一綜述。
목적：유도다공능간세포(induced pluripotent stem cells,IPSCs),방법주요시차조우유도이분화적일충성숙체세포이위,대모일개혹자모일사기인진행표체,진이중신정편득도적일충다공능간세포。결과유도다공능간세포화배태간세포(embryonic stem cells,ESCs)유착일정적상사도,불부부존재고도증치성,동시야존재다향분화잠능,가이분화성위신경원。결론IPSCs구유무도덕윤리장애,무면역배척,취재방식간단、무창등우점,위뇌졸중적세포치료제공료신적희망。현취근년래여iPSCs치료뇌졸중상관적연구작일종술。
Objective To discuss the application potential of induced pluripotent stem cells (iPSCs) in cell therapy for stroke. Methods Under induction and reprogramming, differentiated adult cells can express one or some specific gene, thus changes into a kind of pluripotent stem cells, namely iPSCs. Results A certain degree of similarity can be found between iPSCs and embryonic stem cells stem (ESCs), both of which have highly proliferative ability and multi-directional differentiation potential, for example, differentiation into neurons. Conclusion Without ethical problem and risk of immune rejection, iPSCs was simple to use and nonin-vasive, therefore it can offer hope for patients with stroke. This paper reviews the related research in recent years.
