CAJ | 학술논문

目的：分析ICU危重患者持续镇静治疗的临床效果。方法将该院ICU收治的300例危重患者随机分为丙泊酚组和咪唑地西泮组，各150例，两组患者分别采用丙泊酚联合芬太尼及咪唑地西泮联合芬太尼进行镇静治疗，对两组患者治疗效果进行比较和分析。结果两组患者镇静前后血糖、血清皮质醇、促肾上腺皮质激素及胃液pH值的比较具有明显差异(P<0.05)。丙泊酚组评分为3~5分的患者有137例，占91.33%；咪唑地西泮组评分为3~5分的患者有135例，占90.00%；组间比较差异无统计学意义(P>0.05)。结论采用丙泊酚或咪唑地西泮对ICU危重患者给予镇静治疗，可有效减少患者额的应激反应，有利于危急情况的预防，可帮助患者轻松、安全度过危险期，值得推广使用。
목적：분석ICU위중환자지속진정치료적림상효과。방법장해원ICU수치적300례위중환자수궤분위병박분조화미서지서반조，각150례，량조환자분별채용병박분연합분태니급미서지서반연합분태니진행진정치료，대량조환자치료효과진행비교화분석。결과량조환자진정전후혈당、혈청피질순、촉신상선피질격소급위액pH치적비교구유명현차이(P<0.05)。병박분조평분위3~5분적환자유137례，점91.33%；미서지서반조평분위3~5분적환자유135례，점90.00%；조간비교차이무통계학의의(P>0.05)。결론채용병박분혹미서지서반대ICU위중환자급여진정치료，가유효감소환자액적응격반응，유리우위급정황적예방，가방조환자경송、안전도과위험기，치득추엄사용。
Objective To analyze the clinical effect of the sustained sedation for the critically ill patients in ICU. Methods 300 critically ill patients admitted to ICU were randomized into propofol group (n=150) and imidazole diazepam group (n=150) for seda-tion therapy with either fentanyl in combination with propofol or fentanyl in combination with imidazole diazepam. The efficacies were compared and analyzed between the two therapies. Results There were statistically significant differences between the blood glucose, serum cortisol, adrenocorticotrophin, and gastric fluid pH before treatment and those after treatment in both the two groups (P<0.05). There were 137(91.33%) patients with ramsay sedation score (RSS) of 3~5 in the propofol group and 135 (90.00%) with RSS of 3~5, and there was no statistically significant difference between the two groups (P>0.05). Conclusion Sedation therapy using propofol or imidazole diazepam for critically ill patients in ICU is worthy of promotion because it can reduce their stress re-action, prevent crisis situations and help them pass the critical stage safely.