CAJ | 학술논문

目的：分析注射用七叶皂苷钠不良反应发生的一般规律及特点，为临床合理用药提供参考。方法：采用回顾性研究方法，对某省药品不良反应监测中心ADR报告数据库中2009～2014年注射用七叶皂苷钠ADR／ADE报告进行统计和分析。结果：注射用七叶皂苷钠所致不良反应主要为用药部位损害404例次（28.55％），皮肤及其附件损害374例次（26.43％），全身性损害296例次（20.92％）；ADR／ADE表现较多的有注射部位疼痛、皮疹、静脉炎等。结论：重视注射用七叶皂苷钠引发的不良反应，提高临床合理用药水平，完善药品说明书，防止严重不良反应发生，确保临床用药安全。
목적：분석주사용칠협조감납불량반응발생적일반규률급특점，위림상합리용약제공삼고。방법：채용회고성연구방법，대모성약품불량반응감측중심ADR보고수거고중2009～2014년주사용칠협조감납ADR／ADE보고진행통계화분석。결과：주사용칠협조감납소치불량반응주요위용약부위손해404례차（28.55％），피부급기부건손해374례차（26.43％），전신성손해296례차（20.92％）；ADR／ADE표현교다적유주사부위동통、피진、정맥염등。결론：중시주사용칠협조감납인발적불량반응，제고림상합리용약수평，완선약품설명서，방지엄중불량반응발생，학보림상용약안전。
Objective:To provide references for the clinical rational use of drug by analyzing the general pattern and characteristics of adverse drug reactions caused by Aescine sodium injection .Methods:A total of 1149 ADR/ADE cases of Aescine sodium injection collect-ed by Henan center for ADR monitoring from 2009 to 2014 were analyzed by retrospective study .Results: The main adverse reactions of Aescine sodium injection were administration site disorder (404 cases, 28.55%), skin and appendages disorders (374 cases, 26.43%), whole-general body disorder (296 cases, 20.92%).The common serious reactions were showed as pain at the injection site , erythra, and phlebophlogosis, ect.Conclusion:It is important to pay attention to the ADR/ADE caused by Aescine sodium injection, in order to improve the rational use in clinical, complete the drug specification, prevent serious adverse drug reactions, and ensure clinical medication safety.