中国性科学
中國性科學
중국성과학
Chinese Journal of Human Sexuality
2015年
9期
28-31
,共4页
骨桥蛋白%中性粒细胞明胶酶相关脂质运载蛋白%多囊卵巢综合征
骨橋蛋白%中性粒細胞明膠酶相關脂質運載蛋白%多囊卵巢綜閤徵
골교단백%중성립세포명효매상관지질운재단백%다낭란소종합정
Osteopontin%Neutrophil gelatinase -associated lipocalin%Polycystic ovary syndrome
目的:探讨多囊卵巢综合征(PCOS)患者血清骨桥蛋白(OPN)与中性粒细胞明胶酶相关脂质运载蛋白(NGAL)的水平及其临床意义。方法:62例 PCOS 患者及同期健康体检的30例正常对照者分别采用酶联免疫法(ELISA)检测血清 OPN 和 NGAL 的水平,同时根据体重指数(BMI)将 PCOS 患者分为肥胖组32例(BMI≥25kg/m2)和非肥胖组30例(BMI <25kg/m2)。结果:与正常对照组相比较,所有 PCOS 患者血清中 OPN 和 NGAL 含量均显著偏高;肥胖 PCOS 患者血清中的 OPN 和 NGAL 水平也均明显高于非肥胖 P-COS 患者,差异具有统计学意义(P <0.05)。此外,Pearson 相关分析结果显示血清 OPN 及 NGAL 均与 BMI、胰岛素抵抗指数(HOMA -IR)呈正相关性,与胰岛素敏感指数(ISI)呈负相关性,差异具有统计学意义(P <0.05)。结论:多囊卵巢综合征患者血清中 OPN 和 NGAL 水平均处于升高状态,提示 PCOS 患者机体处于一种慢性炎性状态,未来可将减缓机体炎性状态作为治疗 PCOS 患者的策略之一。
目的:探討多囊卵巢綜閤徵(PCOS)患者血清骨橋蛋白(OPN)與中性粒細胞明膠酶相關脂質運載蛋白(NGAL)的水平及其臨床意義。方法:62例 PCOS 患者及同期健康體檢的30例正常對照者分彆採用酶聯免疫法(ELISA)檢測血清 OPN 和 NGAL 的水平,同時根據體重指數(BMI)將 PCOS 患者分為肥胖組32例(BMI≥25kg/m2)和非肥胖組30例(BMI <25kg/m2)。結果:與正常對照組相比較,所有 PCOS 患者血清中 OPN 和 NGAL 含量均顯著偏高;肥胖 PCOS 患者血清中的 OPN 和 NGAL 水平也均明顯高于非肥胖 P-COS 患者,差異具有統計學意義(P <0.05)。此外,Pearson 相關分析結果顯示血清 OPN 及 NGAL 均與 BMI、胰島素牴抗指數(HOMA -IR)呈正相關性,與胰島素敏感指數(ISI)呈負相關性,差異具有統計學意義(P <0.05)。結論:多囊卵巢綜閤徵患者血清中 OPN 和 NGAL 水平均處于升高狀態,提示 PCOS 患者機體處于一種慢性炎性狀態,未來可將減緩機體炎性狀態作為治療 PCOS 患者的策略之一。
목적:탐토다낭란소종합정(PCOS)환자혈청골교단백(OPN)여중성립세포명효매상관지질운재단백(NGAL)적수평급기림상의의。방법:62례 PCOS 환자급동기건강체검적30례정상대조자분별채용매련면역법(ELISA)검측혈청 OPN 화 NGAL 적수평,동시근거체중지수(BMI)장 PCOS 환자분위비반조32례(BMI≥25kg/m2)화비비반조30례(BMI <25kg/m2)。결과:여정상대조조상비교,소유 PCOS 환자혈청중 OPN 화 NGAL 함량균현저편고;비반 PCOS 환자혈청중적 OPN 화 NGAL 수평야균명현고우비비반 P-COS 환자,차이구유통계학의의(P <0.05)。차외,Pearson 상관분석결과현시혈청 OPN 급 NGAL 균여 BMI、이도소저항지수(HOMA -IR)정정상관성,여이도소민감지수(ISI)정부상관성,차이구유통계학의의(P <0.05)。결론:다낭란소종합정환자혈청중 OPN 화 NGAL 수평균처우승고상태,제시 PCOS 환자궤체처우일충만성염성상태,미래가장감완궤체염성상태작위치료 PCOS 환자적책략지일。
Objectives:To investigate clinical significance of levels of serum osteopontin and neutrophil ge-latinase -associated lipocalin in patients with polycystic ovary syndrome.Methods:The levels of serum levels of OPN and NGAL of 62 PCOS patients and 30 healthy people as normal control were detected by using enzyme -linked immunoassay (ELISA).According to body mass index (BMI),patients with PCOS were divided into two groups:32 cases in obese group (BMI≥25kg/m)2 and 30 cases in non -obese group (BMI <25kg/m2 ).Results:Compared with normal control group,OPN and NGAL content in all PCOS patients were significantly higher.And OPN and NGAL levels of PCOS patients with obese were significantly higher than these of non -obese PCOS patients (P <0.05).In addition,Pearson correlation analysis results showed that there was a positive correlation between the serum levels of OPN and NGAL and BMI,insulin resistance index (HOMA -IR)(P <0.05).Conclusions:Polycystic ovary syndrome patients were under a state of elevated serum levels of OPN and NGAL,which may indi-cate that the PCOS patients maybe in a state of chronic inflammatory.In future,slowing down the body’s inflamma-tory state may become a part of the strategy for the treatment of patients with PCOS.