CAJ | 학술논문

目的：为了进一步提高该院对蛛网膜下腔出血的治疗效果并减少各种不良事件的发生几率，探讨和研究在治疗过程中采取脑脊液置换术的安全性和意义。方法按照随机双盲对照的原则将2014年1月-2015年1月在菏泽市第二人民医院神经外科住院治疗的60例蛛网膜下腔出血患者作为研究对象并分为观察组和对照组，每组各包括患者30例，其中对照组患者在治疗的过程中应用常规方案进行，则观察组患者在常规治疗的基础上采取脑脊液置换术方案治疗，对比和分析两种不同的治疗方案的治疗效果和并发症发生几率。结果经过数据分析得出，观察组患者在7 d、14 d内头痛持续分别为8(26.67%)、3(10.00%)，而对照组患者在7 d、14 d内头痛持续分别为20(66.67%)、12(40.00%)，对照组患者效果明显不如观察组，且两组患者比较差异具有统计学意义(P<0.05)。结论对蛛网膜下腔出现患者在进行常规药物治疗的基础上实施脑脊液置换术治疗，不仅可以提高患者的治疗有效率，而且减少了各种并发症的发生几率，值得临床推广。
목적：위료진일보제고해원대주망막하강출혈적치료효과병감소각충불량사건적발생궤솔，탐토화연구재치료과정중채취뇌척액치환술적안전성화의의。방법안조수궤쌍맹대조적원칙장2014년1월-2015년1월재하택시제이인민의원신경외과주원치료적60례주망막하강출혈환자작위연구대상병분위관찰조화대조조，매조각포괄환자30례，기중대조조환자재치료적과정중응용상규방안진행，칙관찰조환자재상규치료적기출상채취뇌척액치환술방안치료，대비화분석량충불동적치료방안적치료효과화병발증발생궤솔。결과경과수거분석득출，관찰조환자재7 d、14 d내두통지속분별위8(26.67%)、3(10.00%)，이대조조환자재7 d、14 d내두통지속분별위20(66.67%)、12(40.00%)，대조조환자효과명현불여관찰조，차량조환자비교차이구유통계학의의(P<0.05)。결론대주망막하강출현환자재진행상규약물치료적기출상실시뇌척액치환술치료，불부가이제고환자적치료유효솔，이차감소료각충병발증적발생궤솔，치득림상추엄。
Objective To investigate the safety and significance of exchange of cerebrospinal fluid in the treatment of subarachnoid hemorrhage so as to further improve the therapeutic effect and reduce the incidence of adverse events in the treatment of the dis-ease in our hospital. Methods 60 cases with subarachnoid hemorrhage underwent hospitalization in Department of Neurosurgery of Heze Second People's Hospital from January 2014 to January 2015 were selected as the subjects and divided into the observation group and the control group with 30 cases in each in accordance with the random double-blind control principle. Patients in the control group were treated by the conventional regimen, while those in the observation group were treated by exchange of cere-brospinal fluid combined with the conventional regimen. And the therapeutic effect and incidence of complications were compared between the two groups. Results The analysis of the data showed that 8 cases (26.67%) in the observation group while 20 cases (66.67%) in the control group had headache lasting for 7d, 3 cases (10.00%) in the observation group while 12 cases (40.00%) in the control group had headache lasting for 14d, the therapeutic effect of the observation group was much better than that of the control group with statistically significant difference(P<0.05). Conclusion For patients with subarachnoid hemorrhage, conventional drug therapy combined with exchange of cerebrospinal fluid can improve the response rate and reduce the incidence of complica-tions, so it is worthy of clinical promotion.