CAJ | 학술논문

目的：研究不同年龄段高风险妇女人宫颈组织乳头瘤病毒（HPV）的感染及其基因型分布情况。方法：应用导流杂交基因芯片技术（凯普 HPV 分型），对670例女性宫颈脱落细胞 HPV 的21种亚型进行分型检测，并按照年龄分组进行比较结果。结果：总 HPV 感染阳性率为41.0％（275／670），其中≤25岁组总感染率38.9％、高危基因型占71.4％；26～30岁组总感染率29.3％、高危基因型占70.8％；31～40岁组总感染率37.7％、高危基因型占85.6％；41～50岁组总感染率44.6％、高危基因型占79.6％；≥51岁组总感染率53.7％、高危基因型占95.5％。结论：妇女的年龄与 HPV 感染及其基因型分布有密切的关系。因此，妇女的性生活及其免疫功能是 HPV 持续感染的重要因素。
목적：연구불동년령단고풍험부녀인궁경조직유두류병독（HPV）적감염급기기인형분포정황。방법：응용도류잡교기인심편기술（개보 HPV 분형），대670례녀성궁경탈락세포 HPV 적21충아형진행분형검측，병안조년령분조진행비교결과。결과：총 HPV 감염양성솔위41.0％（275／670），기중≤25세조총감염솔38.9％、고위기인형점71.4％；26～30세조총감염솔29.3％、고위기인형점70.8％；31～40세조총감염솔37.7％、고위기인형점85.6％；41～50세조총감염솔44.6％、고위기인형점79.6％；≥51세조총감염솔53.7％、고위기인형점95.5％。결론：부녀적년령여 HPV 감염급기기인형분포유밀절적관계。인차，부녀적성생활급기면역공능시 HPV 지속감염적중요인소。
Objectives:To evaluate the status of infection and genotype distribution of human papilloma vi-rus (HPV)in women of different ages.Methods:The flow -through hybridization and gene chip technology was used to determine the infection and the genotype of HPV in cervical exfoliated cells for 670 women who were divided into different groups based on their ages.Results:The overall infection rate of HPV was 41.0% (275 /670):the positive rate was 38.9%,with 71.4% high risk genotype rate in women less than 26 year -old;the positive rate was 29.3%,with 70.8% high risk genotype rate in women between 26 and 30 year -old;the positive rate was 37.7%,with 85.6% high risk genotype rate in women between 31 and 40 year -old;the positive rate was 44.6%, with 79.6% high risk genotype rate in women between 41 and 50 year -old;the positive rate was 53.7%,with 95.5% high risk genotype rate in women more than 50 year -old.Conclusions:The women’s age is a critical fac-tor in the progress of HPV infection and the genotype distribution,so the sexual life and immune function play an important role in the persistent HPV infection for women at different ages.