中国伤残医学
中國傷殘醫學
중국상잔의학
Chinese Journal of Trauma and Disability Medicine
2015年
20期
31-33
,共3页
重复经颅磁刺激%精神分裂症%幻听%对照研究
重複經顱磁刺激%精神分裂癥%幻聽%對照研究
중복경로자자격%정신분렬증%환은%대조연구
Repetitive transcranial magnetic stimulation%Schizophrenia%Auditory hallucinations%Control study
目的：探讨重复经颅磁刺激（ rTMS）联合奥氮平治疗急性期精神分裂症幻听的疗效及安全性。方法：80例精神分裂症有幻听患者随机分为rTMS治疗组（40例）和对照组（40例）。治疗组给予10次1Hz rTMS刺激治疗，每次20分钟。2组同时给予奥氮平治疗14天。采用阳性与阴性症状量表（ Positive and Negative Syndrome Scale，PANSS）、听幻觉量表（ Auditory Hallucina-tions Rating Scale，AHRS）及临床疗效总评量表（Clinical Global Impression Scale，CGI）评定治疗效果。副反应量表（Treatment E-mergent Symptoms Scale，TESS）评定其副反应。结果：80例患者中，治疗组完成37例，对照组完成36例。研究结束时治疗组PAN-SS P3评分及AHRS评分均低于对照组（t＝5．85，5．10；P＜0．05），但2组PANSS总分及CGI－SI评分差异无统计学意义（t＝1．25，1．56；P＞0．05）。2组不良反应（TESS）差异无统计学意义（x2＝0．34，P＝0．562），均无严重不良反应出现。结论：奥氮平联合低频rTMS治疗精神分裂症的幻听症状疗效明显，且安全性好。
目的：探討重複經顱磁刺激（ rTMS）聯閤奧氮平治療急性期精神分裂癥幻聽的療效及安全性。方法：80例精神分裂癥有幻聽患者隨機分為rTMS治療組（40例）和對照組（40例）。治療組給予10次1Hz rTMS刺激治療，每次20分鐘。2組同時給予奧氮平治療14天。採用暘性與陰性癥狀量錶（ Positive and Negative Syndrome Scale，PANSS）、聽幻覺量錶（ Auditory Hallucina-tions Rating Scale，AHRS）及臨床療效總評量錶（Clinical Global Impression Scale，CGI）評定治療效果。副反應量錶（Treatment E-mergent Symptoms Scale，TESS）評定其副反應。結果：80例患者中，治療組完成37例，對照組完成36例。研究結束時治療組PAN-SS P3評分及AHRS評分均低于對照組（t＝5．85，5．10；P＜0．05），但2組PANSS總分及CGI－SI評分差異無統計學意義（t＝1．25，1．56；P＞0．05）。2組不良反應（TESS）差異無統計學意義（x2＝0．34，P＝0．562），均無嚴重不良反應齣現。結論：奧氮平聯閤低頻rTMS治療精神分裂癥的幻聽癥狀療效明顯，且安全性好。
목적：탐토중복경로자자격（ rTMS）연합오담평치료급성기정신분렬증환은적료효급안전성。방법：80례정신분렬증유환은환자수궤분위rTMS치료조（40례）화대조조（40례）。치료조급여10차1Hz rTMS자격치료，매차20분종。2조동시급여오담평치료14천。채용양성여음성증상량표（ Positive and Negative Syndrome Scale，PANSS）、은환각량표（ Auditory Hallucina-tions Rating Scale，AHRS）급림상료효총평량표（Clinical Global Impression Scale，CGI）평정치료효과。부반응량표（Treatment E-mergent Symptoms Scale，TESS）평정기부반응。결과：80례환자중，치료조완성37례，대조조완성36례。연구결속시치료조PAN-SS P3평분급AHRS평분균저우대조조（t＝5．85，5．10；P＜0．05），단2조PANSS총분급CGI－SI평분차이무통계학의의（t＝1．25，1．56；P＞0．05）。2조불량반응（TESS）차이무통계학의의（x2＝0．34，P＝0．562），균무엄중불량반응출현。결론：오담평연합저빈rTMS치료정신분렬증적환은증상료효명현，차안전성호。
Objective:The efficacy and safety study to acute schizophrenia with auditory hallucination by repetitive transcranial mag-netic stimulation ( rTMS) with olanzapine therapy.Methods:80 schizophrenia with auditory hallucination were randomly divided into treatment group (40 cases) and control group (40 cases) .Treatment group given 1 hz rTMS stimulation ten times, 20 minutes every time. but no rTMS stimulation to control group.At the same time the two groups were given olanzapine treatment for 14 days.By using positive and negative symptoms scale ( PANSS) , auditory hallucinations scale ( AHRS) and the clinical global impression scale( CGI) to evaluate the therapeutic effect.Treatment emergent symptoms scale( TESS) to assess the side effects.Results:37 cases of treatment group com-plete the study, 36 cases of control group complete the study.At the end of the study, P3(hallucinatory behavior) score from PANSS in treatment group and the AHRS score were lower than the control group (t =5.85, 5.10;P <0.05), but the PANSS scores and CGI-SI (severity of illness)were no statistically significant difference in two groups (t =1.25, 1.56;P >0.05).there was no statistically significant difference to TESS in two groups (c2 =0.34, P =0.34), there were no serious adverse reactions.Conclusion:there are obvious curative effect and good safety to schizophrenia with auditory hallucination by Olanzapine combine low frequency rTMS.
