中国药物评价
中國藥物評價
중국약물평개
Chinese Journal of Drug Evaluation
2015年
4期
248-251
,共4页
老年痴呆%药物经济学%多奈哌齐%尼麦角林
老年癡呆%藥物經濟學%多奈哌齊%尼麥角林
노년치태%약물경제학%다내고제%니맥각림
Senile dementia%Pharmacoeconomics%Donepezil%Nicergoline
目的：探讨低剂量多奈哌齐联合尼麦角林治疗老年期痴呆的经济效果。方法：选取我院符合入组标准的门诊老年期痴呆患者25例，随机分为对照组和治疗组。对照组单用高剂量（10 mg?d－1）多奈哌齐治疗，治疗组使用低剂量（5 mg?d－1）多奈哌齐联合尼麦角林治疗，疗程均为6个月。于治疗前、中、后采用简易智能精神状态检查量表（ MMSE）、日常生活能力量表（ADL）、谵妄分级量表－98修订版（DRS－R－98）、临床疗效总评量表（CGI）分别进行评定，并记录每个患者的治疗费用。结果：组内：治疗组与对照组的MMSE评分、DRS评分在治疗前、后的比较，差异均显著，有统计学意义（ P＜0.05）；组间：治疗组与对照组的MMSE评分、DRS评分在治疗前、中、后的比较均无明显差异（ P＞0.05）。治疗组的平均月治疗费用明显低于对照组，差异显著（ P＜0.01），而两组间的疗效指数比较，差异无统计学意义（ P＞0.05）。结论：低剂量多奈哌齐联合尼麦角林治疗老年期痴呆的疗效与单用高剂量多奈哌齐相近，但可显著减少治疗费用，从而减轻社会和家庭的经济负担。
目的：探討低劑量多奈哌齊聯閤尼麥角林治療老年期癡呆的經濟效果。方法：選取我院符閤入組標準的門診老年期癡呆患者25例，隨機分為對照組和治療組。對照組單用高劑量（10 mg?d－1）多奈哌齊治療，治療組使用低劑量（5 mg?d－1）多奈哌齊聯閤尼麥角林治療，療程均為6箇月。于治療前、中、後採用簡易智能精神狀態檢查量錶（ MMSE）、日常生活能力量錶（ADL）、譫妄分級量錶－98脩訂版（DRS－R－98）、臨床療效總評量錶（CGI）分彆進行評定，併記錄每箇患者的治療費用。結果：組內：治療組與對照組的MMSE評分、DRS評分在治療前、後的比較，差異均顯著，有統計學意義（ P＜0.05）；組間：治療組與對照組的MMSE評分、DRS評分在治療前、中、後的比較均無明顯差異（ P＞0.05）。治療組的平均月治療費用明顯低于對照組，差異顯著（ P＜0.01），而兩組間的療效指數比較，差異無統計學意義（ P＞0.05）。結論：低劑量多奈哌齊聯閤尼麥角林治療老年期癡呆的療效與單用高劑量多奈哌齊相近，但可顯著減少治療費用，從而減輕社會和傢庭的經濟負擔。
목적：탐토저제량다내고제연합니맥각림치료노년기치태적경제효과。방법：선취아원부합입조표준적문진노년기치태환자25례，수궤분위대조조화치료조。대조조단용고제량（10 mg?d－1）다내고제치료，치료조사용저제량（5 mg?d－1）다내고제연합니맥각림치료，료정균위6개월。우치료전、중、후채용간역지능정신상태검사량표（ MMSE）、일상생활능역량표（ADL）、섬망분급량표－98수정판（DRS－R－98）、림상료효총평량표（CGI）분별진행평정，병기록매개환자적치료비용。결과：조내：치료조여대조조적MMSE평분、DRS평분재치료전、후적비교，차이균현저，유통계학의의（ P＜0.05）；조간：치료조여대조조적MMSE평분、DRS평분재치료전、중、후적비교균무명현차이（ P＞0.05）。치료조적평균월치료비용명현저우대조조，차이현저（ P＜0.01），이량조간적료효지수비교，차이무통계학의의（ P＞0.05）。결론：저제량다내고제연합니맥각림치료노년기치태적료효여단용고제량다내고제상근，단가현저감소치료비용，종이감경사회화가정적경제부담。
Objective:To investigate the economic effects of the treatment for senile dementia with low dose donepezil jointed nicergo -line.Methods:25 cases of senile dementia patients were randomly divided into the treatment group and the control group .The control group was treated with high dose(10 mg?d-1)donepezil,while the treatment group with low dose(5 mg?d-1) donepezil jointed nicergo-line.The treatment both lasted for 6 months.Before and after treatment , the mini mental state examination ( MMSE) ,activity of daily liv-ing scale (ADL),delirium rating scale revised-98(DRS-R-98), clinical global impression scale (CGI) were evaluated,and the costs of treatment were recorded.Results:Within groups:compared between before and after treating ,the treatment group and the control group both had significant difference in MMSE scores and DRS scores ( P<0.05 );Between groups:compared between the treatment group and the control group ,no matter before and after treatment , there was no significant difference in MMSE scores and DRS scores ( P>0.05 ) . The average monthly cost of the treatment group was significantly lower than the control group (P<0.01),while there was no significant difference in the index of therapeutic effect between 2 groups (P>0.05).Conclusion: Relative to the single high dose donepezil ,low dose donepezil jointed nicergoline has a similar curative effect but can significantly reduce the treatment cost and the family and social e -conomic burden in the treatment for senile dementia .
