CAJ | 학술논문

目的：观察电针对糖尿病胃轻瘫(DGP)大鼠胃动素(MOT)及生长抑素(SS)的影响。方法选取尿糖阴性清洁级健康SD大鼠100只,稳定饲养3 d后,随机选取30只为对照组,其余70只采用链脲佐菌素造模建立胰岛素依赖型糖尿病动物模型,10星期后随机抽取造模成功的大鼠分为模型组和治疗组,每组30只,模型组不做任何治疗,电针组取足三里、中脘、胃俞予电针治疗。观察各组治疗前后血清及胃窦组织MOT和SS变化情况。结果治疗组和模型组大鼠体重及胃肠推进率与对照组比较,差异均具有统计学意义(P＜0.01)。治疗组治疗后体重及胃肠推进率与模型组比较,差异均具有统计学意义(P＜0.01)。治疗组和模型组大鼠造模后、治疗10星期后及治疗后血糖值与对照组比较,差异均具有统计学意义(P＜0.01)。治疗组治疗后血糖值与同组治疗10星期后比较,差异具有统计学意义(P＜0.01)。治疗组和模型组血清及胃窦组织中MOT和SS含量与对照组比较,差异均具有统计学意义(P＜0.01)。治疗组治疗后血清及胃窦组织中MOT和SS含量与模型组比较,差异均具有统计学意义(P＜0.01)。结论电针可使DGP大鼠血清中SS及胃窦组织中MOT显著上升,血清中MOT及胃窦组织中SS相应下降,从而改善DGP大鼠血中高胃动素及高生长抑素状态。
목적：관찰전침대당뇨병위경탄(DGP)대서위동소(MOT)급생장억소(SS)적영향。방법선취뇨당음성청길급건강SD대서100지,은정사양3 d후,수궤선취30지위대조조,기여70지채용련뇨좌균소조모건립이도소의뢰형당뇨병동물모형,10성기후수궤추취조모성공적대서분위모형조화치료조,매조30지,모형조불주임하치료,전침조취족삼리、중완、위유여전침치료。관찰각조치료전후혈청급위두조직MOT화SS변화정황。결과치료조화모형조대서체중급위장추진솔여대조조비교,차이균구유통계학의의(P＜0.01)。치료조치료후체중급위장추진솔여모형조비교,차이균구유통계학의의(P＜0.01)。치료조화모형조대서조모후、치료10성기후급치료후혈당치여대조조비교,차이균구유통계학의의(P＜0.01)。치료조치료후혈당치여동조치료10성기후비교,차이구유통계학의의(P＜0.01)。치료조화모형조혈청급위두조직중MOT화SS함량여대조조비교,차이균구유통계학의의(P＜0.01)。치료조치료후혈청급위두조직중MOT화SS함량여모형조비교,차이균구유통계학의의(P＜0.01)。결론전침가사DGP대서혈청중SS급위두조직중MOT현저상승,혈청중MOT급위두조직중SS상응하강,종이개선DGP대서혈중고위동소급고생장억소상태。
Objective To investigate the effect of electroacupuncture on motilin (MOT) and somatostatin (SS) in rats with diabetes gastroparesis (DGP). Methods One hundred clean healthy SD rats with negative urine glucose were chosen. After they were fed for three days and into a stable state, 30 rats were randomly selected as a control group. The other 70 rats were used as an animal model of insulin-dependent diabetes made with streptozotocin. At 10 weeks after model making, rats as successful models were randomly allocated to model and treatment groups, 30 rats each. The model group received no treatment and the treatment group, electroacupuncture at points Zusanli, Zhongwan and Weishu. Serum and antral MOT and SS were measured in every group before and after treatment. Results There were statistically significant differences in body weight and gastrointestinal propulsion rate between the treatment or model group of rats and the control group (P<0.01), and between the treatment and model groups after treatment (P<0.01). There was a statistically significant difference in blood glucose value between the treatment or model group of rats and the control group after model making and at 10 weeks and the end of treatment (P<0.01). There was a statistically significant difference in blood glucose value between at the end and 10 weeks of treatment in the treatment group (P<0.01). There were statistically significant differences in serum and antral MOT and SS contents between the treatment or model group and the control group (P<0.01), and between the treatment and model groups after treatment (P<0.01). Conclusions Electrocupuncture can markedly increase serum SS and antral MOT and decrease serum MOT and antral SS to ameliorate high blood motilin and somatostatin in DGP rats.