CAJ | 학술논문

Schiff碱金属配合物抗肿瘤活性的研究已逐渐成为配位化学及抗肿瘤药物研究的热点，该文简要介绍了近年来国内、外Schiff碱金属配合物抗肿瘤活性的最新研究进展，揭示了其相关作用机制，并阐述了其作为新型抗肿瘤药的优势。对Schiff碱配体及金属进行合成、改造、组合和筛选，从而合成具有潜力的新型抗肿瘤药物，这对肿瘤化疗药的研发具有重要意义。
Schiff감금속배합물항종류활성적연구이축점성위배위화학급항종류약물연구적열점，해문간요개소료근년래국내、외Schiff감금속배합물항종류활성적최신연구진전，게시료기상관작용궤제，병천술료기작위신형항종류약적우세。대Schiff감배체급금속진행합성、개조、조합화사선，종이합성구유잠력적신형항종류약물，저대종류화료약적연발구유중요의의。
Study on Schiff base metal complexes and their antitumor activities has gradually become the focus of coordina-tion chemistry and antitumor drug research. The article gives brief introduction of recent research development on antitumor activities of Schiff bases and metal complexes, revealing the mechanism of the regulation, and expounding their advantage as a new anticancer drug. Schiff base ligands and metals are synthesized, transformed, combined and screened, so that it can synthesize the novel antitumor drugs, which has important significance for the research and development of tumor chemotherapy drugs.