CAJ | 학술논문

目的：研究肥胖学龄儿童外周血嗜酸性粒细胞( EOS)与肥胖诱导的糖脂代谢紊乱的关系。方法收集天津医科大学总医院儿科内分泌门诊7~14岁肥胖学龄儿童180例(男102例,女78例)。按照外周血EOS百分比将肥胖学龄儿童分为E1组( EOS百分比0~<37%)、E2组( EOS百分比37%~<73%)和E3组( EOS百分比73%~100%)。选取与肥胖组年龄、性别相匹配的正常体质量的儿童46例作为对照组(男26例,女20例)。测量4组学龄儿童身高、体质量、腰围、血压、血常规、空腹血糖( FPG)、空腹胰岛素( FINS)和血脂。比较各组各项体格指标及糖脂代谢指标。结果 E1、E2、E3组外周血EOS百分比、体质量指数( BMI)、三酰甘油、总胆固醇、低密度脂蛋白胆固醇、FINS、FPG、胰岛素抵抗指数( HOMA-IR)、腰围等指标均高于对照组,高密度脂蛋白胆固醇低于对照组,差异均有统计学意义(P均<0．05)。 E1组血压明显高于其他3组,差异有统计学意义(P<0.05)。 E1组BMI、HOMA-IR高于E3组,差异均有统计学意义(P均<0.05)。肥胖组外周血EOS百分比与FINS呈正相关(r=0.190,P=0.01),与BMI、HOMA-IR均呈负相关(r =-0.259、-0.190,P均<0.05)。结论肥胖学龄儿童已出现糖脂代谢紊乱,外周血EOS百分比可能是胰岛素抵抗的早期检测指标之一。
목적：연구비반학령인동외주혈기산성립세포( EOS)여비반유도적당지대사문란적관계。방법수집천진의과대학총의원인과내분비문진7~14세비반학령인동180례(남102례,녀78례)。안조외주혈EOS백분비장비반학령인동분위E1조( EOS백분비0~<37%)、E2조( EOS백분비37%~<73%)화E3조( EOS백분비73%~100%)。선취여비반조년령、성별상필배적정상체질량적인동46례작위대조조(남26례,녀20례)。측량4조학령인동신고、체질량、요위、혈압、혈상규、공복혈당( FPG)、공복이도소( FINS)화혈지。비교각조각항체격지표급당지대사지표。결과 E1、E2、E3조외주혈EOS백분비、체질량지수( BMI)、삼선감유、총담고순、저밀도지단백담고순、FINS、FPG、이도소저항지수( HOMA-IR)、요위등지표균고우대조조,고밀도지단백담고순저우대조조,차이균유통계학의의(P균<0．05)。 E1조혈압명현고우기타3조,차이유통계학의의(P<0.05)。 E1조BMI、HOMA-IR고우E3조,차이균유통계학의의(P균<0.05)。비반조외주혈EOS백분비여FINS정정상관(r=0.190,P=0.01),여BMI、HOMA-IR균정부상관(r =-0.259、-0.190,P균<0.05)。결론비반학령인동이출현당지대사문란,외주혈EOS백분비가능시이도소저항적조기검측지표지일。
Objective To investigate the association of eosinophils with glucose and lipid metabolism disorder in obese children. Methods A total of 180 subjects,102 boys and 78 girls,aged 7 to 14 years were enrolled in General Hospital,Tianjin Medical University. The subjects were divided into 3 quartiles according to eosinophil percentage. E1 (0 to<37% of eosinophils),E2(37% to<73% of eosinophils),and E3(73% to 100% of eosinophils). Forty-six chil-dren were selected as control group with matched age and sex (26 boys and 20 girls). The body weight,height,waist circumference,blood pressure,blood routine examination,fasting plasma glucose (FPG),fasting insulin (FINS),and blood lipid in 4 groups were measured. The values of glucose and lipid metabolism and the indexes of physical examina-tion were compared among each group. Results The values of eosinophil percentage,body mass index (BMI),trig-ly-ceride,total cholesterol, low-density lipoprotein cholesterol, FINS, FPG,homeostasis model assessment of insulin resistance(HOMA-IR) and waist circumference in E1,E2,E3 group were significantly higher than those in control group,and the value of high-density lipoprotein cholesterol was significantly lower than that in control group,and there were significant differences (all P<0. 05). The blood pressure was significantly higher in E1 groups than that in other 3 groups (all P<0. 05). The values of BMI and HOMA-IR in E1 group were higher than those of E3 group(all P<0. 05). Eosinophil percentage was positively correlated with FINS (r=0. 190,P=0. 01),and negatively correlated with BMI and HOMA-IR(r=-0. 259,-0. 190 respectively,all P<0. 05). Conclusions Obese children have emerged glucose and lipid metabolism disorders. Peripheral eosinophil percentage may be an early marker of insulin resistance.