CAJ | 학술논문

目的：尿苷二磷酸葡萄糖醛酸转移酶（ UDP－glucuronosyltransferase ，UGT）是许多内源性和外源性物质在生物体内进行Ⅱ相生物转化时最重要的一种酶，可以把亲脂性底物葡萄糖醛酸化，利于其随尿、胆汁和粪便排出体外。 UGT2B7是UGT家族中重要的一员，主要在肝细胞的内质网和核膜表达，在其他组织细胞如肾、胰腺、脑、肠道等亦有广泛分布。近年来研究发现，UGT2B7基因多态性可能通过参与内源性底物的生物转化影响乳腺癌、子宫内膜癌、结直肠癌、膀胱癌及胆囊癌、甲状腺乳头状癌的发生发展及预后。本文就UGT2B7基因多态性与肿瘤的相关性进行了综述。
목적：뇨감이린산포도당철산전이매（ UDP－glucuronosyltransferase ，UGT）시허다내원성화외원성물질재생물체내진행Ⅱ상생물전화시최중요적일충매，가이파친지성저물포도당철산화，리우기수뇨、담즙화분편배출체외。 UGT2B7시UGT가족중중요적일원，주요재간세포적내질망화핵막표체，재기타조직세포여신、이선、뇌、장도등역유엄범분포。근년래연구발현，UGT2B7기인다태성가능통과삼여내원성저물적생물전화영향유선암、자궁내막암、결직장암、방광암급담낭암、갑상선유두상암적발생발전급예후。본문취UGT2B7기인다태성여종류적상관성진행료종술。
UDP-glucuronosyltransferase enzymes ( UGTs) are an impor-tant class of phase II conjugating enzymes that catalyze the conjugation with UDP-glucuronic acid of many compounds , which subsequently can be excreted via bile or urine . UGT2B7, which is the major UGT isozyme , expressed highly in human liver , with lower levels of expression in other tissues, including kidney, pancreas, brain, and the gastrointes-tinal tract.Recent studies reported that genetic polymorphisms of UGT 2B7 may influence the development and prognosis of caners , including breast cancer , endometrial cancer , colorectal cancer , bladder cancer , gallbla-dder cancer and thyroid papillary carcinoma , which may due to their role in the biotransformation of endogenous substrates .In this paper , the rela-tionship between UGT2B7 polymorphisms and cancers was reviewed .