CAJ | 학술논문

目的：观察不同浓度脊髓康对脊髓损伤大鼠诱发电位的影响。方法 SD大鼠60只，按体重随机分为6组，假手术组、模型组、对照组（强的松，0.06 g· kg－1· d－1）、高中低3个剂量（脊髓康，50，25，12.5 g· kg－1· d－1）实验组。分别于术前和术后即刻及术后3，7，14，28 d对大鼠进行体感诱发电位（ SEP）与运动诱发电位（ MEP）检测，观察潜伏期与波幅的变化。结果中剂量实验组对SEP潜伏期及波幅的改善优于高、低2个剂量实验组，但与对照组比较无明显差异。中剂量实验组对于MEP潜伏期缩短与对照组接近，优于高、低2个剂量实验组，对于波幅的提高优于其他给药组。结论中剂量脊髓康对于脊髓损伤后神经功能恢复具有良好疗效。
목적：관찰불동농도척수강대척수손상대서유발전위적영향。방법 SD대서60지，안체중수궤분위6조，가수술조、모형조、대조조（강적송，0.06 g· kg－1· d－1）、고중저3개제량（척수강，50，25，12.5 g· kg－1· d－1）실험조。분별우술전화술후즉각급술후3，7，14，28 d대대서진행체감유발전위（ SEP）여운동유발전위（ MEP）검측，관찰잠복기여파폭적변화。결과중제량실험조대SEP잠복기급파폭적개선우우고、저2개제량실험조，단여대조조비교무명현차이。중제량실험조대우MEP잠복기축단여대조조접근，우우고、저2개제량실험조，대우파폭적제고우우기타급약조。결론중제량척수강대우척수손상후신경공능회복구유량호료효。
Objective To observe the effects of different concentrations Jisuikang on spinal cord -evoked potentials after spinal cord injury in rats.Methods Sixty SD rats were divided into 6 groups randomly ,sham group, model group, control group(prednisone,0.06 g· kg -1· d-1), the high -dose , mid -dose , low -dose ( Jisuikang , 50 , 25 , 12.5 g· kg -1 · d-1 ) test groups.The sensory evoked potentials ( SEP) and motor evoked potentials ( MEP) were tested at preoperative and postoper-ative 0, 3, 7, 14, 28 d.Then the changes of the incubation period and amplitude were observed.Results Test mid-dose group has precede effect than test-L group and the test -H on the changes of the SEP in-cubation period and amplitude , but no obvious difference compared with control group.The test mid-dose group has the same effect with control group on the MEP incubation period , better than test high -dose group and test low-dose group.Test mid-dose group has precede effect than other groups on the MEP amplitude.Conclusion The mid -dose Jisuikang has the best curative effect for neural functional recovery after spinal cord injury.