CAJ | 학술논문

目的：研究乙醇对丙泊酚催眠效应的影响。方法①按分层随机区组设计将32只小鼠分为4组（n＝8）：30％乙醇组（E30组）、40％乙醇组（E40组）、50％乙醇组（E50组）、60％乙醇组（E60组）。观察小鼠翻正反射消失的比率，确定合适的乙醇浓度。②按分层随机区组设计将40只小鼠分为5组（n ＝8）：生理盐水组（NS组）、脂肪乳组（F 组）、乙醇组（E 组）、丙泊酚组（P 组）及联合组（乙醇＋丙泊酚，U 组）。观察小鼠翻正反射消失率、潜伏期以及翻正反射消失持续时间。结果与 E 组及 P 组相比，U 组翻正反射消失率明显升高（P ＜0．01），潜伏期明显缩短（P ＜0．01），翻正反射消失持续时间明显延长（P ＜0．01）。结论乙醇可显著增强丙泊酚的催眠效应，加强中枢抑制作用。
목적：연구을순대병박분최면효응적영향。방법①안분층수궤구조설계장32지소서분위4조（n＝8）：30％을순조（E30조）、40％을순조（E40조）、50％을순조（E50조）、60％을순조（E60조）。관찰소서번정반사소실적비솔，학정합괄적을순농도。②안분층수궤구조설계장40지소서분위5조（n ＝8）：생리염수조（NS조）、지방유조（F 조）、을순조（E 조）、병박분조（P 조）급연합조（을순＋병박분，U 조）。관찰소서번정반사소실솔、잠복기이급번정반사소실지속시간。결과여 E 조급 P 조상비，U 조번정반사소실솔명현승고（P ＜0．01），잠복기명현축단（P ＜0．01），번정반사소실지속시간명현연장（P ＜0．01）。결론을순가현저증강병박분적최면효응，가강중추억제작용。
Objective To investigate the effects of ethanol on the hypnosis induced by propofol.Methods Based on stratified randomization, 32 mice were divided into four groups (n =8), according to their different treatments of 30%ethanol (Group E30), 40% ethanol (Group E40), 50% ethanol( Group E50) and 60% ethanol (Group E60).Then, the righting reflex test was performed to observe the rate of LOR in order to determine the optimum concentration of etha-nol.Based on stratified randomization, anther 40 mice were divided into five groups (n =8), according to their different treatments of normal saline (Group NS), fat emulsion (Group F), ethanol (Group E), propofol (Group P) and a com-bination of ethanol +propofol (Group U).Then, the righting reflex test was performed to observe the rate, latency and duration of LOR.Results Compared with Groups E and P, Group U produced a remarkably higher rate of LOR (P <0.01), obviously shorter latency (P <0.01), and markedly extended duration (P <0.01).Conclusion Ethanol can strengthen the hypnotic effect of propofol, and enhance the inhabitation of the central nervous system.