CAJ | 학술논문

目的：观察针药并用对溃疡性结肠炎患者T细胞亚群的影响。方法将64例溃疡性结肠炎患者随机分为治疗组和对照组，每组32例。治疗组采用针刺配合药物治疗，对照组采用单纯药物治疗。治疗2个月后，观察两组治疗前后T细胞亚群的变化情况，并比较两组临床疗效。结果治疗组总有效率为87.5%，对照组为75.0%，两组比较差异具有统计学意义(P＜0.05)。治疗组治疗后CD3、CD4及CD4/CD8与同组治疗前比较，差异均具有统计学意义(P＜0.01)。治疗组治疗后各项T细胞亚群指标(CD3、CD4、CD8及CD4/CD8)与对照组比较，差异均具有统计学意义(P＜0.05)。结论针药并用是一种治疗溃疡性结肠炎的有效方法，能调整CD3、CD4的数量，改善患者机体免疫功能。
목적：관찰침약병용대궤양성결장염환자T세포아군적영향。방법장64례궤양성결장염환자수궤분위치료조화대조조，매조32례。치료조채용침자배합약물치료，대조조채용단순약물치료。치료2개월후，관찰량조치료전후T세포아군적변화정황，병비교량조림상료효。결과치료조총유효솔위87.5%，대조조위75.0%，량조비교차이구유통계학의의(P＜0.05)。치료조치료후CD3、CD4급CD4/CD8여동조치료전비교，차이균구유통계학의의(P＜0.01)。치료조치료후각항T세포아군지표(CD3、CD4、CD8급CD4/CD8)여대조조비교，차이균구유통계학의의(P＜0.05)。결론침약병용시일충치료궤양성결장염적유효방법，능조정CD3、CD4적수량，개선환자궤체면역공능。
Objective To investigate the effect of combined use of acupuncture and medicine on T cell subgroups in ulcerative colitis patients. Methods Sixty-four patients with ulcerative colitis were randomly allocated to treatment and control groups, 32 cases each. The treatment group received acupuncture plus medication and the control group, medication alone. After two months of treatment, changes in T cell subgroups were observed in the two groups and the clinical therapeutic effects were compared between the two groups. Results The total efficacy rate was 87.5% in the treatment group and 75.5% in the control group; there was a statistically significant difference between the two groups (P<0.05). There were statistically significant pre-/post-treatment differences in CD3, CD4 and CD4/CD8 in the treatment group (P<0.05). There were statistically significant post-treatment differences in T cell subgroup indices (CD3, CD4 and CD4/CD8) between the treatment and control groups (P<0.05). Conclusions Combined use of acupuncture and medicine is an effective way to treat ulcerative colitis. It can regulate the numbers of CD3 and CD4 and improve bodily immunologic function in the patients.