CAJ | 학술논문

用TaqMan 探针技术,在Fluidigm EPI 平台上对安徽蚌埠地区汉族617例Graves 病(GD)患者和4915名健康对照者4p14区段上rs6832151位点进行基因分型。结果显示,4p14区段rs6832151 G 与 Graves 病易感性有统计学意义(OR =1.39,P<0.01)；且根据该位点基因分型构建的三种遗传模型(累加模型、显性模型、隐性模型)均具有显著统计学意义(均P<0.01)；甲状腺肿大程度在该位点基因型亚组之间的差异无统计学意义(P>0.05)。提示4p14上rs6832151的G 等位基因为蚌埠地区人群GD 的易感基因,显著增加GD 的发病风险。
용TaqMan 탐침기술,재Fluidigm EPI 평태상대안휘방부지구한족617례Graves 병(GD)환자화4915명건강대조자4p14구단상rs6832151위점진행기인분형。결과현시,4p14구단rs6832151 G 여 Graves 병역감성유통계학의의(OR =1.39,P<0.01)；차근거해위점기인분형구건적삼충유전모형(루가모형、현성모형、은성모형)균구유현저통계학의의(균P<0.01)；갑상선종대정도재해위점기인형아조지간적차이무통계학의의(P>0.05)。제시4p14상rs6832151적G 등위기인위방부지구인군GD 적역감기인,현저증가GD 적발병풍험。
[Summary] The genotypes of rs6832151 in the 4p14 were genotyped by Taqman probe technique on FluidigmEPl platform in 617 patients with Graves′disease( GD) and 4 915 health control subjects. The result showed thatRs6832151 Gin4p14wasstronglyassociatedwithGD(OR=1.39,P<0.01),withstatisticalsignificancefor three genetic models according to the locus genotyping ( additive model,dominant model,and recessive model,all P<0.01). There was no statistically significant difference in the sizes of goiter between the genotype subgroups(P>0. 05). The result suggests that rs6832151 G in 4p14 is the susceptibility genes of Graves′ disease in Bengbu population, and is related to the high risk of GD.