CAJ | 학술논문

在江苏省徐州市中心医院收集健康体检者1510人,根据血清TSH 水平分为3组：低TSH 水平组(0.30~0.99 mIU/ L),中TSH 水平组(1.00~1.89 mIU/ L)和高TSH 水平组(1.90~4.80 mIU/ L)。采用方差分析、线性回归分析血清TSH 水平与血压、空腹血糖及血脂之间的相关性。结果显示,3组间收缩压、舒张压、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)水平差异均有统计学意义(P <0.05或P <0.01)。单因素线性回归分析显示血清TSH 水平与收缩压及舒张压呈负相关(P<0.05或P<0.01),与TG 及HDL-C 呈正相关(P<0.05或P<0.01),但经校正后相关性消失。在男性人群中,多元线性回归分析显示血清TSH 水平与收缩压、空腹血糖呈负相关(P<0.05)。
재강소성서주시중심의원수집건강체검자1510인,근거혈청TSH 수평분위3조：저TSH 수평조(0.30~0.99 mIU/ L),중TSH 수평조(1.00~1.89 mIU/ L)화고TSH 수평조(1.90~4.80 mIU/ L)。채용방차분석、선성회귀분석혈청TSH 수평여혈압、공복혈당급혈지지간적상관성。결과현시,3조간수축압、서장압、감유삼지(TG)、고밀도지단백담고순(HDL-C)수평차이균유통계학의의(P <0.05혹P <0.01)。단인소선성회귀분석현시혈청TSH 수평여수축압급서장압정부상관(P<0.05혹P<0.01),여TG 급HDL-C 정정상관(P<0.05혹P<0.01),단경교정후상관성소실。재남성인군중,다원선성회귀분석현시혈청TSH 수평여수축압、공복혈당정부상관(P<0.05)。
[Summary] A total of 1 510 subjects undergoing physical examination in the Central Hospital of Xuzhou were included in this study. According to the level of TSH, the subjects were divided into low TSH group(0. 30-0. 99 mIU/L,n=351), moderate TSH group(1. 00-1. 89 mIU/L, n=703), and high TSH group(1. 90-4. 80 mIU/L, n=456). Analysis of variance and linear regression were used for data analysis. The results showed that systolic blood pressure ( SBP) , diastolic blood pressure ( DBP) , triglyceride ( TG) , and high-density lipoprotein cholesterol( HDL-C) revealed significant differences among 3 group(P<0. 05 or P<0. 01). In the univariate linear regression model, serumTSHwithinthereferencerangewasnegativelyassociatedwithSBPandDBP(P<0.05orP<0.01),and positively associated with TG and HDL-C (P<0. 05 or P<0. 01). However, the correlations disappeared after adjustment for gender, age, body mass index, fasting plasma glucose ( FPG ) , and TG. In the multiple linear regression model, a significant negative correlation of TSH with SBP and FPG was found in males(P<0. 05).