实用心脑肺血管病杂志
實用心腦肺血管病雜誌
실용심뇌폐혈관병잡지
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
2015年
8期
118-120
,共3页
赵碎巧%李娟%操银针%李信华
趙碎巧%李娟%操銀針%李信華
조쇄교%리연%조은침%리신화
脑梗死%益肾定眩汤%尤瑞克林%C反应蛋白质%神经肽Y%皮质醇
腦梗死%益腎定眩湯%尤瑞剋林%C反應蛋白質%神經肽Y%皮質醇
뇌경사%익신정현탕%우서극림%C반응단백질%신경태Y%피질순
Brain infarction%Yi-shen ding-xuan decoction%Kallikrein%C-reactive protein%Neuropeptide Y%Cortisol
目的：探讨益肾定眩汤联合尤瑞克林治疗急性脑梗死的临床疗效及其对血清C反应蛋白（ CRP）、神经肽Y（ NPY）及皮质醇水平的影响。方法选取2013—2014年武汉市汉口医院神经内科收治的急性脑梗死患者124例，按照随机数字表法分为观察组和对照组，各62例。对照组患者给予尤瑞克林治疗，观察组患者给予益肾定眩汤联合尤瑞克林治疗，均治疗14 d。比较两组患者治疗前及治疗后24 h、72 h、7 d美国国立卫生研究院卒中量表（ NIHSS）评分，治疗前后血清CRP、NPY及皮质醇水平及临床疗效。结果观察组患者临床疗效优于对照组（ u=3.166，P<0.05）。治疗前两组患者NIHSS评分比较，差异无统计学意义（ P>0.05）；治疗后24 h、72 h、7 d 观察组患者NIHSS评分均低于对照组（P<0.05）。治疗前两组患者血清CRP、NPY及皮质醇水平比较，差异无统计学意义（P>0.05）；治疗后观察组患者血清CRP、NPY及皮质醇水平均低于对照组（ P<0.05）。结论益肾定眩汤联合尤瑞克林治疗急性脑梗死的临床疗效确切，能有效改善患者神经功能，降低血清CRP、NPY和皮质醇水平。
目的：探討益腎定眩湯聯閤尤瑞剋林治療急性腦梗死的臨床療效及其對血清C反應蛋白（ CRP）、神經肽Y（ NPY）及皮質醇水平的影響。方法選取2013—2014年武漢市漢口醫院神經內科收治的急性腦梗死患者124例，按照隨機數字錶法分為觀察組和對照組，各62例。對照組患者給予尤瑞剋林治療，觀察組患者給予益腎定眩湯聯閤尤瑞剋林治療，均治療14 d。比較兩組患者治療前及治療後24 h、72 h、7 d美國國立衛生研究院卒中量錶（ NIHSS）評分，治療前後血清CRP、NPY及皮質醇水平及臨床療效。結果觀察組患者臨床療效優于對照組（ u=3.166，P<0.05）。治療前兩組患者NIHSS評分比較，差異無統計學意義（ P>0.05）；治療後24 h、72 h、7 d 觀察組患者NIHSS評分均低于對照組（P<0.05）。治療前兩組患者血清CRP、NPY及皮質醇水平比較，差異無統計學意義（P>0.05）；治療後觀察組患者血清CRP、NPY及皮質醇水平均低于對照組（ P<0.05）。結論益腎定眩湯聯閤尤瑞剋林治療急性腦梗死的臨床療效確切，能有效改善患者神經功能，降低血清CRP、NPY和皮質醇水平。
목적：탐토익신정현탕연합우서극림치료급성뇌경사적림상료효급기대혈청C반응단백（ CRP）、신경태Y（ NPY）급피질순수평적영향。방법선취2013—2014년무한시한구의원신경내과수치적급성뇌경사환자124례，안조수궤수자표법분위관찰조화대조조，각62례。대조조환자급여우서극림치료，관찰조환자급여익신정현탕연합우서극림치료，균치료14 d。비교량조환자치료전급치료후24 h、72 h、7 d미국국립위생연구원졸중량표（ NIHSS）평분，치료전후혈청CRP、NPY급피질순수평급림상료효。결과관찰조환자림상료효우우대조조（ u=3.166，P<0.05）。치료전량조환자NIHSS평분비교，차이무통계학의의（ P>0.05）；치료후24 h、72 h、7 d 관찰조환자NIHSS평분균저우대조조（P<0.05）。치료전량조환자혈청CRP、NPY급피질순수평비교，차이무통계학의의（P>0.05）；치료후관찰조환자혈청CRP、NPY급피질순수평균저우대조조（ P<0.05）。결론익신정현탕연합우서극림치료급성뇌경사적림상료효학절，능유효개선환자신경공능，강저혈청CRP、NPY화피질순수평。
Objective To investigate the clinical effect of yi-shen ding-xuan decoction combined with urinarykallid on acute cerebral infarction and its impact on serum levels of CRP,NPY and cortisol. Methods Between 2013 and 2014,a total of 124 patients with acute cerebral infarction were selected in the Department of Neurology,Hankou Hospital of Wuhan,and they were divided into observation group and control group according to random number table,each of 62 cases. Patients of control group were given urinarykallid,while patients of observation group were given yi -shen ding -xuan decoction combined with urinarykallid,both groups treated for 14 days. NIHSS score before treatment and after 24 hours,72 hours,7 days of treatment, serum levels of CRP, NPY and cortisol before and after treatment, clinical effect were compared between the two groups. Results The clinical effect of observation group was statistically significantly better than that of control group(u=3. 166,P<0. 05). No statistically significant differences of NIHSS score was found between the two groups before treatment(P>0. 05), while NIHSS score of observation group was statistically significantly lower than that of control group after 24 hours,72 hours,7 days of treatment,respectively(P<0. 05). No statistically significant differences of serum levels of CRP,NPY or cortisol was found between the two groups before treatment(P>0. 05),while serum levels of CRP,NPY and cortisol of observation group were statistically significantly lower than those of control group after treatment(P<0. 05). Conclusion Yi-shen ding-xuan decoction combined with urinarykallid has certain clinical effect on acute cerebral infarction,which can effectively improve the neurological function,reduce the serum levels of CRP,NPY and cortisol.
