CAJ | 학술논문

目的：探讨腰围身高比( WHtR)预测非超重人群代谢综合征( MS)的效力和适宜切点,分析年龄性别差异的影响。方法选择参加2010年浙江省MS流行病学调查的10792名年龄≥18周岁非超重居民(体重指数<24.0 kg/m2)为研究对象,进行问卷调查、体格检查和MS相关组分检测,分性别和年龄组应用受试者工作特征曲线分析WHtR预测MS的曲线下面积( AUC)和最佳切点,采用多因素logistic回归模型进行WHtR与MS患病风险分析。结果 WHtR预测非超重男性和女性MS的AUC值分别为0.765(95%CI 0.740~0.789)和0.786(95%CI 0.765~0.807),WHtR与非超重男性和女性MS患病风险的OR值分别为1.23(95%CI 1.20~1.27)和1.22(95%CI 1.20~1.26),不同性别、年龄组AUC值和OR值均有显著性(P<0.01)；AUC值和OR值在18~34岁组为女性大于男性,年龄≥35岁各组均为男性大于女性；随着年龄增长,AUC值和OR值在男性各年龄组略呈波动,在女性各年龄组逐渐减小。预测最佳切点女性高于男性(0.509对0.498),男性最佳切点以50~64岁组最高,女性最佳切点随年龄增长呈升高趋势。结论 WHtR对非超重人群MS患病风险具有较好的预测效力和相关性,但应考虑年龄性别差异的影响。
목적：탐토요위신고비( WHtR)예측비초중인군대사종합정( MS)적효력화괄의절점,분석년령성별차이적영향。방법선택삼가2010년절강성MS류행병학조사적10792명년령≥18주세비초중거민(체중지수<24.0 kg/m2)위연구대상,진행문권조사、체격검사화MS상관조분검측,분성별화년령조응용수시자공작특정곡선분석WHtR예측MS적곡선하면적( AUC)화최가절점,채용다인소logistic회귀모형진행WHtR여MS환병풍험분석。결과 WHtR예측비초중남성화녀성MS적AUC치분별위0.765(95%CI 0.740~0.789)화0.786(95%CI 0.765~0.807),WHtR여비초중남성화녀성MS환병풍험적OR치분별위1.23(95%CI 1.20~1.27)화1.22(95%CI 1.20~1.26),불동성별、년령조AUC치화OR치균유현저성(P<0.01)；AUC치화OR치재18~34세조위녀성대우남성,년령≥35세각조균위남성대우녀성；수착년령증장,AUC치화OR치재남성각년령조략정파동,재녀성각년령조축점감소。예측최가절점녀성고우남성(0.509대0.498),남성최가절점이50~64세조최고,녀성최가절점수년령증장정승고추세。결론 WHtR대비초중인군MS환병풍험구유교호적예측효력화상관성,단응고필년령성별차이적영향。
Objective To evaluate the utility of waist-to-height ratio ( WHtR ) in predicting metabolic syndrome ( MS) among non-overweight Chinese adults, and to investigate the difference by age and sex. Methods Based on a population-based cross-sectional survey on MS in Zhejiang province in 2010, data of 10 792 non-overweight (body mass index<24. 0 kg/m2 ) adults aged 18 years and older were analyzed by using the receiver operating characteristic(ROC)curve analysis and multiple logistic regression. Results The area under ROC curve (AUC) values of WHtR in MS prediction were 0. 765(95%CI 0. 740-0. 789) and 0. 786(95%CI 0. 765-0. 807), and odds ratios(OR) of WHtR for MS were 1. 23(95%CI 1. 20-1. 27) and 1. 22(95%CI 1. 20-1. 26) in non-overweight men and women, respectively. These two values were with significant difference among non-overweight adults with different agedandsexes(P<0.01). No-overweightmenhadsmallerAUCandORamong18-34agegroupwhilelargerAUCand OR among 35-49, 50-64, and 65-plus age groups than women. The AUC and OR showed slight difference among age groups in non-overweight men, while these two values decreased with age in non-overweight women. The optimal cutoff value was higher in non-overweight women (0. 509 vs 0. 498) than that in men. Non-overweight men aged 50-64 years old had higher cutoff value than those aged 18-34, 35-49, and 65-plus years, while among non-overweight women the cutoff values increased with age. Conclusion WHtR had preferable discriminatory power and association with MS among non-overweight Chinese adults. Further studies should be conducted to explore the difference by age and sex.