CAJ | 학술논문

目的：综合评价2型糖尿病患者应用磺脲类降糖药物与脑中风风险性的关联性。方法通过文献检索收集符合入组条件随机对照研究( random control trails, RCT),比较2型糖尿病患者应用磺脲类药物与对照剂相比脑中风发生风险差异。使用Stata 12.0和Rev Man 5.2进行meta分析,以漏斗图检验入选文献的发表偏倚。结果纳入RCT研究17项,采用随机效应模型对脑中风发生事件进行分析,应用磺脲类降糖药物组脑中风风险性较对照组升高(RR 1.35,95% CI 1.13~1.60)。17项研究异质性I2值为0.0%(P=0.687),漏斗图显示纳入研究间未见明显发表偏倚。结论2型糖尿病患者应用磺脲类降糖药物有可能是潜在脑中风风险性升高的危险因素。
목적：종합평개2형당뇨병환자응용광뇨류강당약물여뇌중풍풍험성적관련성。방법통과문헌검색수집부합입조조건수궤대조연구( random control trails, RCT),비교2형당뇨병환자응용광뇨류약물여대조제상비뇌중풍발생풍험차이。사용Stata 12.0화Rev Man 5.2진행meta분석,이루두도검험입선문헌적발표편의。결과납입RCT연구17항,채용수궤효응모형대뇌중풍발생사건진행분석,응용광뇨류강당약물조뇌중풍풍험성교대조조승고(RR 1.35,95% CI 1.13~1.60)。17항연구이질성I2치위0.0%(P=0.687),루두도현시납입연구간미견명현발표편의。결론2형당뇨병환자응용광뇨류강당약물유가능시잠재뇌중풍풍험성승고적위험인소。
Objective To investigate whether sulfonylurea ( SU) increases the risk of stroke in patients with type 2 diabetes mellitus(T2DM). Methods A systemic meta-analysis including 17 random control trails(RCT) was performed to compare the risk of stroke between type 2 diabetic patients treated with SUs and comparators. Results 1 612 articles were retrieved, and finally 17 articles were included. Patients receiving SUs treatment had a higher relative risk of stroke (RR 1. 35, 95% CI 1. 13-1. 60) than those who received comparators. The I2 statistic for heterogeneity between 17 trails was 0. 0%(P=0. 687). No major asymmetry appeared in the funnel plot and Begg′adjusted rank correlation test(kendall′s score=22, P=0. 387). Conclusion The use of SUs may raise the risk of stroke which is already high in patients with T2DM.