CAJ | 학술논문

目的：观察参芍片对不稳定型心绞痛( UA )的临床疗效。方法将入选的120例UA病人随机分为两组，在常规治疗的基础上，观察组单服参芍片，对照组同时服用硝酸异山梨酯(消心痛)片和氯吡格雷片，均连续用药4周。观察其用药前后的临床症状、心电图、血小板聚集和血液黏度。结果观察组和对照组心绞痛疗效总有效率分别为83.3%、81.7%，心电图变化总有效率分别为75.0%、73.3%，两组心绞痛疗效和心电图变化总有效率比较，差异无统计学意义(P＞0.05)；两组治疗后与治疗前血小板聚集及血液黏度比较，差异有统计学意义(P＜0.05)，但两组治疗后比较，差异无统计学意义(P＞0.05)。两组均未发生严重不良反应。结论参芍片可改善心肌供血，抑制血小板聚集，降低血液黏度，且安全。
목적：관찰삼작편대불은정형심교통( UA )적림상료효。방법장입선적120례UA병인수궤분위량조，재상규치료적기출상，관찰조단복삼작편，대조조동시복용초산이산리지(소심통)편화록필격뢰편，균련속용약4주。관찰기용약전후적림상증상、심전도、혈소판취집화혈액점도。결과관찰조화대조조심교통료효총유효솔분별위83.3%、81.7%，심전도변화총유효솔분별위75.0%、73.3%，량조심교통료효화심전도변화총유효솔비교，차이무통계학의의(P＞0.05)；량조치료후여치료전혈소판취집급혈액점도비교，차이유통계학의의(P＜0.05)，단량조치료후비교，차이무통계학의의(P＞0.05)。량조균미발생엄중불량반응。결론삼작편가개선심기공혈，억제혈소판취집，강저혈액점도，차안전。
Objective To observe the clinical effects of Shenshao tablets in the treatm ent of unstable angina pectoris (UA ).Methods 120 patients with UA were divided random ly into tw o groups,on the basis of routine therapy,the ob-servation group were just given Shenshao tablets,w hile the control group at the same time were given isosorbide dini-trate and clopidogrel tablets,both groups had continuous adm inistration for 4 w eeks.The clinical sym ptom s,electrocar-diogram,platelet aggregation and blood viscosity before and after m edication were observed .Results The total curative effect rates of UA in the observation group and the control group were 83.3% and 81.7% respectively,and the total curative effect rates of electrocardiogramchanges in both groups were 75.0% and 73.3% respectively.C om parison of the total curative effect rates of UA and electrocardiogramchanges in both groups show ed no difference of statistical significance (P>0 .05 ).C om parison of platelet aggregation and blood viscosity before and after m edication in both groups show ed differences of statistical significance (P<0 .05 ).B ut com parison in the tw o groups after treatm ent show ed no difference of statistical significance (P>0 .05 ).There were not serious adverse reactions in the tw o groups. Conclusion Shenshao tablets can improve m yocardial blood supply,inhibit platelet aggregation,and reduce blood vis-cosity with safety.