CAJ | 학술논문

目的：了解癌痛患者使用羟考酮治疗剂量的影响因素，为正确给予癌痛患者镇痛治疗提供依据。方法：以医院HIS系统为数据来源，调取我院2012年4月1日至2015年2月28日使用羟考酮缓释片治疗的患者病例320份，采用Mann－Whitney检验方法比较不同因素（性别、年龄、职业、肿瘤有无骨转移及有无爆发痛）对癌痛患者羟考酮治疗剂量的影响，采用Kruskal－Wallis检验方法比较疼痛程度对癌痛患者羟考酮治疗剂量的影响。结果：不同性别、年龄、职业、疼痛程度癌痛患者的羟考酮最大日剂量差异无统计学意义，而有无爆发痛组的羟考酮最大日剂量差异有统计学意义。结论：通过对患者性别、年龄、职业、疼痛程度、有无爆发痛等可能影响羟考酮最大日剂量的因素进行分析，依据目前数据总结研究有无爆发痛是影响羟考酮最大日剂量的一个因素。
목적：료해암통환자사용간고동치료제량적영향인소，위정학급여암통환자진통치료제공의거。방법：이의원HIS계통위수거래원，조취아원2012년4월1일지2015년2월28일사용간고동완석편치료적환자병례320빈，채용Mann－Whitney검험방법비교불동인소（성별、년령、직업、종류유무골전이급유무폭발통）대암통환자간고동치료제량적영향，채용Kruskal－Wallis검험방법비교동통정도대암통환자간고동치료제량적영향。결과：불동성별、년령、직업、동통정도암통환자적간고동최대일제량차이무통계학의의，이유무폭발통조적간고동최대일제량차이유통계학의의。결론：통과대환자성별、년령、직업、동통정도、유무폭발통등가능영향간고동최대일제량적인소진행분석，의거목전수거총결연구유무폭발통시영향간고동최대일제량적일개인소。
Objective:To analyze the factors affecting therapeutic dose of oxycodone hydrochloride prolonged -release tablets for treat-ment on cancer-pain patients.Methods:The research of hospital information system (HIS)data from one general hospital comprising 320 patients was carried out .Oxycodone hydrochloride prolonged-release tablet was used to ease their pains .The Mann-Whitney test was ap-plied to compare the relationship between flex , age, job, tumor metastasis, pain degree, breakthrough pain and the therapeutic dose.Results:There was statistical meaning for the differences on therapeutic doses in terms of breakthrough pain .But, there was no sta-tistical meaning for the differences on therapeutic doses in terms of gender , age, job, tumor metastasis and pain degree .Conclusion:Breakthrough pain is the factor affecting therapeutic dose of oxycodone hydrochloride prolonged -release tablets for treatment on cancer-pain patients.