CAJ | 학술논문

目的：观察美罗培南3种不同输注方式治疗重症肺炎的临床疗效。方法：选取ICU重症肺炎患者60例，随机分为3组：传统输注组（A组）、延长输注组（B组）和优化两步输注组（C组）。 A组输注方案为美罗培南1 g溶于0.9％的氯化钠注射液100 mL中，8 h／次，持续30 min；B组输注方案为美罗培南1 g溶于0.9％的氯化钠注射液50 mL中，8 h／次，微量推注泵持续3 h泵入；C组输注方案为美罗培南1 g溶于0.9％的氯化钠注射液50 mL中，在前0.25 h泵入400 mg，在其后2.75 h泵入600 mg，总共泵入时间为3 h，8 h／次。比较3组患者的体温、白细胞变化值、临床疗效、病原学疗效以及不良反应发生率等相关指标。结果：给药72 h后，白细胞计数变化值C组与A组比较具有统计学意义（ P≤0.05）；体温下降幅度C组与A组及B组比较具有统计学意义（ P≤0.05）。停药当天， C组临床有效率高于A 组（ P≤0.05）；细菌清除率 C组高于A 组及 B 组（ P≤0.05）。结论：3种不同输注方式中，优化两步输注组治疗重症肺炎的临床疗效优于传统输注组和延长输注组。
목적：관찰미라배남3충불동수주방식치료중증폐염적림상료효。방법：선취ICU중증폐염환자60례，수궤분위3조：전통수주조（A조）、연장수주조（B조）화우화량보수주조（C조）。 A조수주방안위미라배남1 g용우0.9％적록화납주사액100 mL중，8 h／차，지속30 min；B조수주방안위미라배남1 g용우0.9％적록화납주사액50 mL중，8 h／차，미량추주빙지속3 h빙입；C조수주방안위미라배남1 g용우0.9％적록화납주사액50 mL중，재전0.25 h빙입400 mg，재기후2.75 h빙입600 mg，총공빙입시간위3 h，8 h／차。비교3조환자적체온、백세포변화치、림상료효、병원학료효이급불량반응발생솔등상관지표。결과：급약72 h후，백세포계수변화치C조여A조비교구유통계학의의（ P≤0.05）；체온하강폭도C조여A조급B조비교구유통계학의의（ P≤0.05）。정약당천， C조림상유효솔고우A 조（ P≤0.05）；세균청제솔 C조고우A 조급 B 조（ P≤0.05）。결론：3충불동수주방식중，우화량보수주조치료중증폐염적림상료효우우전통수주조화연장수주조。
Objective:To investigate the efficacy of different infusion methods of meropenem in the treatment of severe pneumonia . Methods:60 cases of patients with severe pneumonia from ICU , were randomly divided into traditional infusion group (A group),extend infusion group(B group) and manual control group (C group).In A group, meropenem 1 g was added into 100 mL NS(0.9%) intrave-nous infusion for 30 min, every 8 h at a time.In B group, meropenem 1 g was added into 50 mL NS(0.9%) using micro pump intrave-nously for 3 h, every 8 h at a time.In C group, meropenem 1 g was added into 50 mL NS(0.9%).Pump in 400 mg within 0.25 h, the rest of the 600 mg within 2.75 h, every 8 h at a time.At last, the changes of body temperature and white blood cell count;the bacterial clearance rate;the incidence of adverse reactions and another indicators of the three groups were compared .Results:After 72 h of mero-penem administration , statistical significant difference was obeserved on white blood cell counts of the C group and A group ( P≤0.05 );compared with A group , the temperature in B group significantly dereased ( P≤0.05 );On the withdrawal day , the clinical efficiency and bacterial clearance rate were C group better than A group and B group (P≤0.05).Conclusion:Meropenem in the manual control infu-sion on severe pneumonia′s treatment has better efficacy than others .