中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
Chinese Journal of Endocrinology and Metabolism
2015年
9期
748-751
,共4页
糖尿病, 2型%miR-146a%糖尿病周围神经病变
糖尿病, 2型%miR-146a%糖尿病週圍神經病變
당뇨병, 2형%miR-146a%당뇨병주위신경병변
Diabetes mellitus,type 2%miR-146a%Diabetic peripheral neuropathy
目的：探讨2型糖尿病合并周围神经病变( DPN)患者外周血单个核细胞( PBMCs)中miR-146a的表达及与DPN病情严重程度的相关性。方法应用实时荧光定量PCR检测62例2型糖尿病患者(单纯2型糖尿病32例、伴DPN 30例)及33名健康对照者PBMCs miR-146a的表达水平,并且与2型糖尿病患者临床指标进行相关性分析。结果2型糖尿病组miR-146a的表达低于对照组(1.92±1.99对4.15±1.56,P<0.05),DPN组miR-146a表达水平低于单纯2型糖尿病组(1.22±1.61对2.51±2.00, P<0.05)。DPN组miR-146a的表达水平与病程、多伦多评分、血糖呈负相关。结论 DPN患者外周血miR-146a表达下降,其表达水平与DPN病情严重程度有关。
目的：探討2型糖尿病閤併週圍神經病變( DPN)患者外週血單箇覈細胞( PBMCs)中miR-146a的錶達及與DPN病情嚴重程度的相關性。方法應用實時熒光定量PCR檢測62例2型糖尿病患者(單純2型糖尿病32例、伴DPN 30例)及33名健康對照者PBMCs miR-146a的錶達水平,併且與2型糖尿病患者臨床指標進行相關性分析。結果2型糖尿病組miR-146a的錶達低于對照組(1.92±1.99對4.15±1.56,P<0.05),DPN組miR-146a錶達水平低于單純2型糖尿病組(1.22±1.61對2.51±2.00, P<0.05)。DPN組miR-146a的錶達水平與病程、多倫多評分、血糖呈負相關。結論 DPN患者外週血miR-146a錶達下降,其錶達水平與DPN病情嚴重程度有關。
목적：탐토2형당뇨병합병주위신경병변( DPN)환자외주혈단개핵세포( PBMCs)중miR-146a적표체급여DPN병정엄중정도적상관성。방법응용실시형광정량PCR검측62례2형당뇨병환자(단순2형당뇨병32례、반DPN 30례)급33명건강대조자PBMCs miR-146a적표체수평,병차여2형당뇨병환자림상지표진행상관성분석。결과2형당뇨병조miR-146a적표체저우대조조(1.92±1.99대4.15±1.56,P<0.05),DPN조miR-146a표체수평저우단순2형당뇨병조(1.22±1.61대2.51±2.00, P<0.05)。DPN조miR-146a적표체수평여병정、다륜다평분、혈당정부상관。결론 DPN환자외주혈miR-146a표체하강,기표체수평여DPN병정엄중정도유관。
Objective To investigate the expression levels of miR-146a in the peripheral blood mononuclear cells ( PBMCs ) of patients with diabetic peripheral neuropathy ( DPN ) and their correlation with the disease severity. Methods The expression levels of miR-146a in the PBMCs were measured by using real time PCR in 62 patients with type 2 diabetes (32 patients without DPN, 30 with DPN) and 33 healthy individuals. The correlation of miR-146a expression with clinical parameters was analyzed. Results The expression level of miR-146a in patients withtype2diabetesmellituswassignificantlylowerthanthatinthehealthyindividuals((1.92±1.99vs4.15±1.56, P<0. 05). Furthermore, the miR-146a level was significantly lowered in diabetic patients with DPN as compared with thosewithoutDPN(1.22±1.61vs2.51±2.00,P<0.05). TheexpressionlevelsofmiR-146ainpatientswithDPN were positively correlated with duration of diabetes, blood glucose, and Toronto clinical scoring system scores. Conclusion The decreased expression of miR-146a in patients with DPN is correlated with the severity of DPN.
