CAJ | 학술논문

1例50岁卵巢浆液性交界性肿瘤患者行全子宫、双侧附件及大网膜部分切除术后接受紫杉醇联合卡铂化疗（紫杉醇198 mg、卡铂395 mg 静脉滴注，第1天；21 d 为1个周期）。第3周期化疗静脉给药后，患者出现双手手指麻痛，呈持续性、进行性加重，放射至肘关节。给予口服卡马西平和甲钴胺后未缓解。考虑患者症状与化疗药物有关，暂停辅助化疗，给予泼尼松、瑞巴派特、注射用鼠神经生长因子、甲钴胺等对症治疗。14 d 后，患者疼痛症状减轻。半年后随访，患者右侧大鱼际肌轻度萎缩，双侧食指和中指掌面感觉减退。
1례50세란소장액성교계성종류환자행전자궁、쌍측부건급대망막부분절제술후접수자삼순연합잡박화료（자삼순198 mg、잡박395 mg 정맥적주，제1천；21 d 위1개주기）。제3주기화료정맥급약후，환자출현쌍수수지마통，정지속성、진행성가중，방사지주관절。급여구복잡마서평화갑고알후미완해。고필환자증상여화료약물유관，잠정보조화료，급여발니송、서파파특、주사용서신경생장인자、갑고알등대증치료。14 d 후，환자동통증상감경。반년후수방，환자우측대어제기경도위축，쌍측식지화중지장면감각감퇴。
A 50-year-old female patient with serious borderline tumor received chemotherapy with paclitaxel and carboplatin(an IV infusion of paclitaxel 198 mg and carboplatin 395 mg on the first day of treatment,the cycle of treatment was 21 d)after undergoing total hysterectomy,bilateral ovarian,and greater omentum resection. After the IV infusion of third chemotherapy cycle,the patient developed persistent and progressive numbness and pain of fingers which could radiate to the elbow. After treatment with carbamazepine and mecobalamin,the symptoms were not relieved. Thus it was considered that the adverse reactions may be caused by chemotherapy drugs. So the chemotherapy was paused temporarily,and prednisone,rebamipide,mouse nerve growth factor for injection,and mecobalamin were given. After 14 d of treatments,the patientˊ s symptoms were alleviated apparently. At half a year of follow-up,the patient developed slight atrophy in the right thenar muscle and hypoesthesia in bilateral index finger and middle finger palm.