中华检验医学杂志
中華檢驗醫學雜誌
중화검험의학잡지
Chinese Journal of Laboratory Medicine
2015年
9期
642-645
,共4页
补体C1 q%肾疾病%移植物排斥%动脉粥样硬化%衰老
補體C1 q%腎疾病%移植物排斥%動脈粥樣硬化%衰老
보체C1 q%신질병%이식물배척%동맥죽양경화%쇠로
Complement C1q%Kidney diseases%Graft rejection%Atherosclerosis%Aging
补体系统具有调节吞噬、清除细胞、参与免疫应答和介导炎性反应等多项生物学功能。补体系统的关键组分C1q,除了作为补体经典激活途径的启动子激活级联反应清除抗原抗体复合物,还参与清除凋亡细胞、帮助维持血管内皮细胞的完整性。当C1 q缺失、消耗过多或功能低下,会诱发肾病、动脉粥样硬化、中枢神经系统疾病的发生发展,而且C1 q与衰老相关。因此,监测血清C1 q水平变化有助于疾病的早发现、早治疗,可作为疾病疗效评估和预后观察的有效指标。(中华检验医学杂志,2015,38:642-645)
補體繫統具有調節吞噬、清除細胞、參與免疫應答和介導炎性反應等多項生物學功能。補體繫統的關鍵組分C1q,除瞭作為補體經典激活途徑的啟動子激活級聯反應清除抗原抗體複閤物,還參與清除凋亡細胞、幫助維持血管內皮細胞的完整性。噹C1 q缺失、消耗過多或功能低下,會誘髮腎病、動脈粥樣硬化、中樞神經繫統疾病的髮生髮展,而且C1 q與衰老相關。因此,鑑測血清C1 q水平變化有助于疾病的早髮現、早治療,可作為疾病療效評估和預後觀察的有效指標。(中華檢驗醫學雜誌,2015,38:642-645)
보체계통구유조절탄서、청제세포、삼여면역응답화개도염성반응등다항생물학공능。보체계통적관건조분C1q,제료작위보체경전격활도경적계동자격활급련반응청제항원항체복합물,환삼여청제조망세포、방조유지혈관내피세포적완정성。당C1 q결실、소모과다혹공능저하,회유발신병、동맥죽양경화、중추신경계통질병적발생발전,이차C1 q여쇠로상관。인차,감측혈청C1 q수평변화유조우질병적조발현、조치료,가작위질병료효평고화예후관찰적유효지표。(중화검험의학잡지,2015,38:642-645)
The complement cascade, as a part of innate immune system, plays a major role in phagocytosis, clearance of apoptotic cells, immune response and inflammation.As an initiator of the classical pathway, C1q not only facilitates apoptotic debris removal but also gets involved in the maintenance of vascular endothelial integrity.As a result, deficiency, excessive consumption or dysfunction of C1q leads to the imbalance of such mechanisms and increases the susceptibility of nephropathy, atherosclerosis and central nervous system diseases.Recenlty, C1q was identified as a new biomarker of aging.C1q could be a useful indicator for early diagnosis, therapy and prognosis.