CAJ | 학술논문

目的：探究慢性肾功能不全患者应用前列地尔治疗的临床效果。方法随机选取该院2008年9月-2014年10月住院部60例慢性肾功能不全患者作为该次医学研究对象,所有患者均采取随机数字表法分为实验组与对照组,两组患者采取不同的治疗方案进行临床治疗,对照组患者予以常规保肾药物治疗,实验组患者在对照组治疗基础上加用前列地尔治疗,观察对比两组患者治疗临床效果、不良反应及血肌酐、血尿素氮、血尿酸、24 h尿量等各项指标变化情况。结果两组患者经临床治疗后疗效比较,实验组总有效率为90.00%,对照组为76.67%,实验组显著高于对照组,差异有统计学意义(P<0.05)；实验组患者治疗后血肌酐、血尿素氮、血尿酸、24 h尿量等各项指标均明显优于对照组,差异有统计学意义(P<0.05)；实验组治疗后出现1例静脉炎,1例头痛,对照组患者治疗后出现1例恶心,两组患者总不良反应均较低,差异无统计学意义(P>0.05)。结论慢性肾功能不全患者在常规治疗的基础上联合前列地尔治疗具有显著的临床效果,可提升治疗总有效率,明显改善患者血肌酐、血尿酸及24 h尿量等各项指标,且不良反应少,安全性高,具有较高的临床推广与应用价值。
목적：탐구만성신공능불전환자응용전렬지이치료적림상효과。방법수궤선취해원2008년9월-2014년10월주원부60례만성신공능불전환자작위해차의학연구대상,소유환자균채취수궤수자표법분위실험조여대조조,량조환자채취불동적치료방안진행림상치료,대조조환자여이상규보신약물치료,실험조환자재대조조치료기출상가용전렬지이치료,관찰대비량조환자치료림상효과、불량반응급혈기항、혈뇨소담、혈뇨산、24 h뇨량등각항지표변화정황。결과량조환자경림상치료후료효비교,실험조총유효솔위90.00%,대조조위76.67%,실험조현저고우대조조,차이유통계학의의(P<0.05)；실험조환자치료후혈기항、혈뇨소담、혈뇨산、24 h뇨량등각항지표균명현우우대조조,차이유통계학의의(P<0.05)；실험조치료후출현1례정맥염,1례두통,대조조환자치료후출현1례악심,량조환자총불량반응균교저,차이무통계학의의(P>0.05)。결론만성신공능불전환자재상규치료적기출상연합전렬지이치료구유현저적림상효과,가제승치료총유효솔,명현개선환자혈기항、혈뇨산급24 h뇨량등각항지표,차불량반응소,안전성고,구유교고적림상추엄여응용개치。
Objective To explore the application among patients with chronic renal insufficiency, the clinical effect of treatment. Methods Selected from September 2008 to October 2014 the inpatient 60 cases of patients with chronic renal insufficiency as the medical research object, all the patients were taken random number table method was divided into experimental group and control group, two groups of patients take different treatment for clinical treatment, control group patients give regular kidney drug treat-ment, treatment group patients in the control group on the basis of the total lead to treatment, observation compared two groups of patients clinical effect, adverse reaction and serum creatinine, blood urea nitrogen, blood uric acid, urine volume changes the indi-cators such as 24 hours a day. Results Two groups of patients after treatment with clinical curative effect comparison of the experi-mental group, the total effective rate was 90.00%in the control group was 76.67%, the experimental group was significantly higher than that of control group, P< 0.05, the difference is statistically significant; The experimental group after treatment in patients with serum creatinine, blood urea nitrogen, blood uric acid, 24-hour urine, etc. Each index is better than the control group, P<0.05, the difference is statistically significant; 1 case of phlebitis after experimental treatment, 1 case of headache, the control group after treatment in patients with 1 case of nausea, two groups of patients have adverse reactions are lower, and there was no statistically significant difference (P>0.05).Conclusion Patients with chronic renal insufficiency in the united front on the basis of conventional treatment, treatment has significant clinical effect, can promote total effective treatment, improve patient's serum cre-atinine, blood uric acid and 24 hours urine output indicators, such as, less adverse reaction, high safety, has high clinical popular-ization and application value.