CAJ | 학술논문

1例47岁男性患者因双侧基底节区腔隙性脑梗死给予依达拉奉30 mg 静脉滴注，2次/ d。用药3 d 后患者出现巩膜黄染，实验室检查示天冬氨酸转氨酶（AST）269 U/ L，丙氨酸转氨酶（ALT）1944 U/ L，γ-谷氨酰转移酶（γ-GT）133 U/ L，总胆红素100.0μmol/ L，血小板计数（PLT）70×109/ L，考虑为药源性肝损伤及血小板减少。停用依达拉奉注射液，给予多烯磷酯酰胆碱注射液465 mg 静脉滴注，1次/ d。7 d 后患者巩膜黄染消失，AST 44 U/ L，ALT 187 U/ L，γ-GT 148 U/ L，总胆红素25.4μmol/ L， PLT 121×109/ L；12 d 后 AST 39 U/ L，ALT 77 U/ L，γ-GT 126 U/ L。
1례47세남성환자인쌍측기저절구강극성뇌경사급여의체랍봉30 mg 정맥적주，2차/ d。용약3 d 후환자출현공막황염，실험실검사시천동안산전안매（AST）269 U/ L，병안산전안매（ALT）1944 U/ L，γ-곡안선전이매（γ-GT）133 U/ L，총담홍소100.0μmol/ L，혈소판계수（PLT）70×109/ L，고필위약원성간손상급혈소판감소。정용의체랍봉주사액，급여다희린지선담감주사액465 mg 정맥적주，1차/ d。7 d 후환자공막황염소실，AST 44 U/ L，ALT 187 U/ L，γ-GT 148 U/ L，총담홍소25.4μmol/ L， PLT 121×109/ L；12 d 후 AST 39 U/ L，ALT 77 U/ L，γ-GT 126 U/ L。
A 47-year-old man received an IV infusion of edaravone 30 mg twice daily for acute cerebral infarction. Three days later,the patient developed yellowish sclera. Laboratory examination showed the following levels:aspartate aminotransferase(AST)269 U/ L,alanine aminotransferase(ALT)1 944 U/ L,γ-glutamyl transpeptidase( γ-GT)133 U/ L,total bilirubin( TBil)100. 01 μmol/ L,and platelet count 70 × 109 / L. The patient was diagnosed as severe liver injury and thrombocytopenia due to edaravone injection. Edaravone was stopped and an IV infusion of polyene phosphatidylcholine 465 mg once daily was given. Seven days later,the patientˊs yellowish sclera disappeared. Laboratory examination showed AST 44 U/ L,ALT 187 U/ L,γ-GT 148 U/ L,TBil 25. 4 μmol/ L,and platelet count 121 × 109 / L. Twelve days later,reexaminations showed AST 39 U/ L,ALT 77 U/ L,and γ-GT 126 U/ L.