CAJ | 학술논문

1例有系统性红斑狼疮（SLE）病史15年的41岁女性患者，因子宫内膜增生口服地屈孕酮10 mg，2次/ d，连服7 d。服药4 d 后渐出现面部红色斑丘疹。次月同样剂量服用14 d，皮疹加重，渐发展至全身性脓疱病。实验室检查和 SLE 疾病活动性指数评分除外 SLE 活动复发以及其他感染性疾病、中毒性疾病和肿瘤性疾病，考虑为地屈孕酮引起的自身免疫性黄体酮皮炎。停用地屈孕酮，给予抗过敏治疗2个月，患者症状好转。随诊3个月，未再出现皮疹。
1례유계통성홍반랑창（SLE）병사15년적41세녀성환자，인자궁내막증생구복지굴잉동10 mg，2차/ d，련복7 d。복약4 d 후점출현면부홍색반구진。차월동양제량복용14 d，피진가중，점발전지전신성농포병。실험실검사화 SLE 질병활동성지수평분제외 SLE 활동복발이급기타감염성질병、중독성질병화종류성질병，고필위지굴잉동인기적자신면역성황체동피염。정용지굴잉동，급여항과민치료2개월，환자증상호전。수진3개월，미재출현피진。
A 41-year-old woman with systemic lupus erythematosus ( SLE ) took 10 mg dydrogesterone orally twice daily for 7 days for endometrial hyperplasia. Four days after dydrogesterone administration,she developed red maculopapule on her face. She took dydrogesterone at the same dosage for 14 days for second month and developed more severe rashes and generalized exanthematous pustulosis. Active SLE,infections,intoxication or tumors were excluded by lab examinations and SLE disease activity index scores and autoimmune progesterone dermatitis induced by dydrogesterone was diagnosed. Dydrogesterone was stopped and antianaphylaxis treatment was given. Two months later,her symptoms improved gradually and no skin rash was found at 3-month follow-up.