现代中西医结合杂志
現代中西醫結閤雜誌
현대중서의결합잡지
Modern Journal of Integrated Traditional Chinese and Western Medicine
2015年
27期
2971-2973,2976
,共4页
肝安煎剂%慢性乙型肝炎%肝纤维化
肝安煎劑%慢性乙型肝炎%肝纖維化
간안전제%만성을형간염%간섬유화
Gan’ an decoction%chronic hepatitis B%liver fibrosis
目的：观察自拟中药肝安煎剂治疗慢性乙型肝炎肝纤维化的临床疗效。方法将112例符合条件的慢性乙型肝炎肝纤维化患者随机分为治疗组和对照组，每组56例。治疗组给予肝安煎剂每次200 mL 3次／d口服；对照组给予复方鳖甲软肝片每次2 g 3次／d口服。2组均治疗6个月，观察治疗前后肝功能、肝纤维化相关指标、主要临床症状及彩色多普勒检查结果的变化情况。结果治疗组临床总有效率明显高于对照组（P＜0．05）。2组治疗后主要症状积分和彩色多普勒检查指标均较治疗前明显改善（P均＜0．05），血清总胆红素、丙氨酸转氨酶、天门冬氨酸转氨酶、透明质酸、层黏连蛋白、Ⅲ型前胶原及Ⅳ型胶原水平均较治疗前明显下降（P均＜0．05），血清白蛋白水平均较治疗前明显升高（P均＜0．05），且治疗组上述指标改善情况均明显优于对照组（P均＜0．05）。2组均无药物不良反应发生。结论肝安煎剂可明显减轻慢性乙型肝炎肝纤维化患者的临床症状，有效改善肝功能和抗肝纤维化，值得临床应用。
目的：觀察自擬中藥肝安煎劑治療慢性乙型肝炎肝纖維化的臨床療效。方法將112例符閤條件的慢性乙型肝炎肝纖維化患者隨機分為治療組和對照組，每組56例。治療組給予肝安煎劑每次200 mL 3次／d口服；對照組給予複方鱉甲軟肝片每次2 g 3次／d口服。2組均治療6箇月，觀察治療前後肝功能、肝纖維化相關指標、主要臨床癥狀及綵色多普勒檢查結果的變化情況。結果治療組臨床總有效率明顯高于對照組（P＜0．05）。2組治療後主要癥狀積分和綵色多普勒檢查指標均較治療前明顯改善（P均＜0．05），血清總膽紅素、丙氨痠轉氨酶、天門鼕氨痠轉氨酶、透明質痠、層黏連蛋白、Ⅲ型前膠原及Ⅳ型膠原水平均較治療前明顯下降（P均＜0．05），血清白蛋白水平均較治療前明顯升高（P均＜0．05），且治療組上述指標改善情況均明顯優于對照組（P均＜0．05）。2組均無藥物不良反應髮生。結論肝安煎劑可明顯減輕慢性乙型肝炎肝纖維化患者的臨床癥狀，有效改善肝功能和抗肝纖維化，值得臨床應用。
목적：관찰자의중약간안전제치료만성을형간염간섬유화적림상료효。방법장112례부합조건적만성을형간염간섬유화환자수궤분위치료조화대조조，매조56례。치료조급여간안전제매차200 mL 3차／d구복；대조조급여복방별갑연간편매차2 g 3차／d구복。2조균치료6개월，관찰치료전후간공능、간섬유화상관지표、주요림상증상급채색다보륵검사결과적변화정황。결과치료조림상총유효솔명현고우대조조（P＜0．05）。2조치료후주요증상적분화채색다보륵검사지표균교치료전명현개선（P균＜0．05），혈청총담홍소、병안산전안매、천문동안산전안매、투명질산、층점련단백、Ⅲ형전효원급Ⅳ형효원수평균교치료전명현하강（P균＜0．05），혈청백단백수평균교치료전명현승고（P균＜0．05），차치료조상술지표개선정황균명현우우대조조（P균＜0．05）。2조균무약물불량반응발생。결론간안전제가명현감경만성을형간염간섬유화환자적림상증상，유효개선간공능화항간섬유화，치득림상응용。
Objective It is to observe the clinical effect of self-formulated Gan’ an decoction on chronic hepatitis B with hepatic fibrosis.Methods 112 cases of chronic hepatitis B patients with hepatic fibrosis were randomly divided into treatment group and control group, 56 cases in each group.The cases were treated with Gan’ an decoction ( daily one dose, 200 mL a time and 3 times a day) in the treatment group and with Fufang Biejia Ruangan troche (2g a time, 3 times a day) in the con-trol group.All patients were treated for 6 months, then the changes of liver function, liver fibrosis related index, the major clinical symptoms and colored ultrasonic scanning were observed before and after treatment.Results The clinical total effective rate of the treatment group was markedly higher than that of the control group (P<0.05).After treatment, the improvements of the major clinical symptom integral and colored ultrasonic scanning in both groups were significantly better than before treat-ment (all P<0.05);the serum total bilirubin (TBil), alanine aminotransferase (ALT), aspartate aminotransferase (AST), hyaluronic acid ( HA) , laminin ( LN) ,Ⅲ-procollagen ( PCⅢ) ,Ⅳ-collagen (Ⅳ-C) were all markedly lower ( all P<0.05) and albumin (ALB) was higher (P<0.05) markedly than before treatment, and All the statistics mentioned of the treatment group were significant better than the control group ( all P<0.05) .There were no adverse drug reactions.Conclu-sion Gan’ an decoction can relieve the clinical symptoms, improve the hepatic function and has a better anti-hepatic fibrosis effect.
