现代中西医结合杂志
現代中西醫結閤雜誌
현대중서의결합잡지
Modern Journal of Integrated Traditional Chinese and Western Medicine
2015年
27期
2968-2970
,共3页
刘君%黄凤德%胡晋太%岳明全
劉君%黃鳳德%鬍晉太%嶽明全
류군%황봉덕%호진태%악명전
乳腺浸润性导管癌%血管内皮细胞生长因子-C%磷酸化蛋白激酶B%淋巴结转移
乳腺浸潤性導管癌%血管內皮細胞生長因子-C%燐痠化蛋白激酶B%淋巴結轉移
유선침윤성도관암%혈관내피세포생장인자-C%린산화단백격매B%림파결전이
breast invasive ductal carcinoma%vascular endothelial growth factor%protein kinase B%lymphnode metastasis
目的:探讨乳腺浸润性导管癌(IDC)组织磷酸化蛋白激酶B(p-AKT)、血管内皮细胞生长因子-C( VEGF-C)表达水平,及其与淋巴结侵袭转移的关系。方法应用免疫组织化学法检测72例乳腺IDC组织及30例乳腺腺瘤组织中p-AKT、VEGF-C的表达水平,分析p-AKT与血管生成的关系。结果乳腺IDC组织中VEGF、p-AKT蛋白的阳性表达率分别为59%和67%,均显著高于乳腺腺瘤组织中20%和17%的阳性表达率(χ2=13.39,21.21,P<0.05);与有淋巴结转移者比较,无淋巴结转移的乳腺IDC组织VEGF-C、p-AKT蛋白阳性表达率显著降低(χ2=11.10,5.51,P<0.05);乳腺IDC组织VEGF-C、p-AKT蛋白表达水平呈显著正相关(r=0.823,P<0.05)。结论乳腺IDC组织中VEGF-C、p-AKT呈过度表达状态,共同参与淋巴结的侵袭与转移,阻断PI3K/AKT通路有望为乳腺IDC的靶向治疗提供一种新的思路。
目的:探討乳腺浸潤性導管癌(IDC)組織燐痠化蛋白激酶B(p-AKT)、血管內皮細胞生長因子-C( VEGF-C)錶達水平,及其與淋巴結侵襲轉移的關繫。方法應用免疫組織化學法檢測72例乳腺IDC組織及30例乳腺腺瘤組織中p-AKT、VEGF-C的錶達水平,分析p-AKT與血管生成的關繫。結果乳腺IDC組織中VEGF、p-AKT蛋白的暘性錶達率分彆為59%和67%,均顯著高于乳腺腺瘤組織中20%和17%的暘性錶達率(χ2=13.39,21.21,P<0.05);與有淋巴結轉移者比較,無淋巴結轉移的乳腺IDC組織VEGF-C、p-AKT蛋白暘性錶達率顯著降低(χ2=11.10,5.51,P<0.05);乳腺IDC組織VEGF-C、p-AKT蛋白錶達水平呈顯著正相關(r=0.823,P<0.05)。結論乳腺IDC組織中VEGF-C、p-AKT呈過度錶達狀態,共同參與淋巴結的侵襲與轉移,阻斷PI3K/AKT通路有望為乳腺IDC的靶嚮治療提供一種新的思路。
목적:탐토유선침윤성도관암(IDC)조직린산화단백격매B(p-AKT)、혈관내피세포생장인자-C( VEGF-C)표체수평,급기여림파결침습전이적관계。방법응용면역조직화학법검측72례유선IDC조직급30례유선선류조직중p-AKT、VEGF-C적표체수평,분석p-AKT여혈관생성적관계。결과유선IDC조직중VEGF、p-AKT단백적양성표체솔분별위59%화67%,균현저고우유선선류조직중20%화17%적양성표체솔(χ2=13.39,21.21,P<0.05);여유림파결전이자비교,무림파결전이적유선IDC조직VEGF-C、p-AKT단백양성표체솔현저강저(χ2=11.10,5.51,P<0.05);유선IDC조직VEGF-C、p-AKT단백표체수평정현저정상관(r=0.823,P<0.05)。결론유선IDC조직중VEGF-C、p-AKT정과도표체상태,공동삼여림파결적침습여전이,조단PI3K/AKT통로유망위유선IDC적파향치료제공일충신적사로。
Objective It is to investigate the expression of vascular endothelial growth factor (VEGF), protein kinase B (P-AKT) in breast invasive ductal carcinoma (IDC), and its relation with lymph node invasion and metastasis.Methods The expression of p-AKT, VEGF-C in the tissue of 72 cases of breast IDC and 30 cases of breast fibroadenoma were detec-ted by immunohistochemical staining, the correlation between p-AKT and angiogenesis were analyzed.Results The positive expression rate of p-AKT, VEGF-C protein in breast IDC was 59%and 67%respectively, which was significantly higher than that in breast fibroadenoma of 20%and 17%respectively (χ2 =13.39, 21.21, all P<0.05).The expressions of p-AKT, VEGF-C in breast IDC with lymphnode metastasis were higher than those without lymphnode metastasis (χ2 =11.10, 5.51, all P<0.05).The positive expression rate of VEGF-C had significant positive correlation with that of p-AKT (r=0.823, P<0.05).Conclusion The expression of p-AKT, VEGF-C in breast IDC is over-expressive, and participate the lymphnode invasion and metastasis.Inhibition of PI 3K/AKT signal transduction pathway can be expected to provide a new method for the target therapy of breast IDC.