现代中西医结合杂志
現代中西醫結閤雜誌
현대중서의결합잡지
Modern Journal of Integrated Traditional Chinese and Western Medicine
2015年
27期
2968-2970
,共3页
刘君%黄凤德%胡晋太%岳明全
劉君%黃鳳德%鬍晉太%嶽明全
류군%황봉덕%호진태%악명전
乳腺浸润性导管癌%血管内皮细胞生长因子-C%磷酸化蛋白激酶B%淋巴结转移
乳腺浸潤性導管癌%血管內皮細胞生長因子-C%燐痠化蛋白激酶B%淋巴結轉移
유선침윤성도관암%혈관내피세포생장인자-C%린산화단백격매B%림파결전이
breast invasive ductal carcinoma%vascular endothelial growth factor%protein kinase B%lymphnode metastasis
目的：探讨乳腺浸润性导管癌（IDC）组织磷酸化蛋白激酶B（p－AKT）、血管内皮细胞生长因子－C（ VEGF－C）表达水平，及其与淋巴结侵袭转移的关系。方法应用免疫组织化学法检测72例乳腺IDC组织及30例乳腺腺瘤组织中p－AKT、VEGF－C的表达水平，分析p－AKT与血管生成的关系。结果乳腺IDC组织中VEGF、p－AKT蛋白的阳性表达率分别为59％和67％，均显著高于乳腺腺瘤组织中20％和17％的阳性表达率（χ2＝13.39，21．21，P＜0．05）；与有淋巴结转移者比较，无淋巴结转移的乳腺IDC组织VEGF－C、p－AKT蛋白阳性表达率显著降低（χ2＝11．10，5．51，P＜0．05）；乳腺IDC组织VEGF－C、p－AKT蛋白表达水平呈显著正相关（r＝0．823，P＜0．05）。结论乳腺IDC组织中VEGF－C、p－AKT呈过度表达状态，共同参与淋巴结的侵袭与转移，阻断PI3K／AKT通路有望为乳腺IDC的靶向治疗提供一种新的思路。
目的：探討乳腺浸潤性導管癌（IDC）組織燐痠化蛋白激酶B（p－AKT）、血管內皮細胞生長因子－C（ VEGF－C）錶達水平，及其與淋巴結侵襲轉移的關繫。方法應用免疫組織化學法檢測72例乳腺IDC組織及30例乳腺腺瘤組織中p－AKT、VEGF－C的錶達水平，分析p－AKT與血管生成的關繫。結果乳腺IDC組織中VEGF、p－AKT蛋白的暘性錶達率分彆為59％和67％，均顯著高于乳腺腺瘤組織中20％和17％的暘性錶達率（χ2＝13.39，21．21，P＜0．05）；與有淋巴結轉移者比較，無淋巴結轉移的乳腺IDC組織VEGF－C、p－AKT蛋白暘性錶達率顯著降低（χ2＝11．10，5．51，P＜0．05）；乳腺IDC組織VEGF－C、p－AKT蛋白錶達水平呈顯著正相關（r＝0．823，P＜0．05）。結論乳腺IDC組織中VEGF－C、p－AKT呈過度錶達狀態，共同參與淋巴結的侵襲與轉移，阻斷PI3K／AKT通路有望為乳腺IDC的靶嚮治療提供一種新的思路。
목적：탐토유선침윤성도관암（IDC）조직린산화단백격매B（p－AKT）、혈관내피세포생장인자－C（ VEGF－C）표체수평，급기여림파결침습전이적관계。방법응용면역조직화학법검측72례유선IDC조직급30례유선선류조직중p－AKT、VEGF－C적표체수평，분석p－AKT여혈관생성적관계。결과유선IDC조직중VEGF、p－AKT단백적양성표체솔분별위59％화67％，균현저고우유선선류조직중20％화17％적양성표체솔（χ2＝13.39，21．21，P＜0．05）；여유림파결전이자비교，무림파결전이적유선IDC조직VEGF－C、p－AKT단백양성표체솔현저강저（χ2＝11．10，5．51，P＜0．05）；유선IDC조직VEGF－C、p－AKT단백표체수평정현저정상관（r＝0．823，P＜0．05）。결론유선IDC조직중VEGF－C、p－AKT정과도표체상태，공동삼여림파결적침습여전이，조단PI3K／AKT통로유망위유선IDC적파향치료제공일충신적사로。
Objective It is to investigate the expression of vascular endothelial growth factor (VEGF), protein kinase B (P-AKT) in breast invasive ductal carcinoma (IDC), and its relation with lymph node invasion and metastasis.Methods The expression of p-AKT, VEGF-C in the tissue of 72 cases of breast IDC and 30 cases of breast fibroadenoma were detec-ted by immunohistochemical staining, the correlation between p-AKT and angiogenesis were analyzed.Results The positive expression rate of p-AKT, VEGF-C protein in breast IDC was 59%and 67%respectively, which was significantly higher than that in breast fibroadenoma of 20%and 17%respectively (χ2 =13.39, 21.21, all P<0.05).The expressions of p-AKT, VEGF-C in breast IDC with lymphnode metastasis were higher than those without lymphnode metastasis (χ2 =11.10, 5.51, all P<0.05).The positive expression rate of VEGF-C had significant positive correlation with that of p-AKT (r=0.823, P<0.05).Conclusion The expression of p-AKT, VEGF-C in breast IDC is over-expressive, and participate the lymphnode invasion and metastasis.Inhibition of PI 3K/AKT signal transduction pathway can be expected to provide a new method for the target therapy of breast IDC.
