CAJ | 학술논문

目的：探讨支原体肺炎合并胸腔积液患儿的血清与胸腔积液炎性指标变化情况。方法应用ELISA 双抗体夹心法对胸腔积液组（32例）、支原体肺炎组（30例）、对照组（35例）等三组的血清与胸腔积液白介素6（IL-6）、IL-2及肿瘤坏死因子α（TNF-α）等炎性指标水平进行检测和比较。结果支原体肺炎组 IL-6（9．93±1．05）pg／mL，IL-2（4．93±0．55）μg／mL，TNF-α（1．45±0．17）ng／mL，明显高于对照组，而 IL-2则明显低于对照组，差异均有统计学意义（t ＝6．25、5．88、4．63、5．95、3．69、3．69，均 P ＜0．05）。胸腔积液组血清IL-6、TNF-α水平明显高于支原体肺炎组，而 IL-2则明显低于支原体肺炎组，差异均有统计学意义（t ＝4．02、3．06、2．88，均 P ＜0．05）。大量积液患者血清 IL-6、IL-2及 TNF-α等水平与其他两组差异有统计学意义（均P ＜0．05）。胸腔积液组和支原体肺炎组胸腔积液 IL-6、TNF-α检测水平明显高于对照组，而 IL-2则明显低于对照组，差异均有统计学意义（t ＝5．69、3．69、6．02、4．11、2．94、3．67，均 P ＜0．05）。胸腔积液组胸腔积液IL-6、TNF-α水平明显高于支原体肺炎组，而 IL-2则明显低于支原体肺炎组，差异均有统计学意义（t ＝3．58、4．13、3．21，均 P ＜0．05）。大量积液患者胸腔积液 IL-6、IL-2及 TNF-α水平与其他两组差异有统计学意义（t ＝6．11、5．44、4．82，均 P ＜0．05）。结论IL-6、IL-2及 TNF-α在肺炎支原体肺炎的发生发展过程中起重要作用，罹患支原体肺炎合并胸腔积液患者胸腔积液中 TNF-α、IL-6等炎性指标以及患者血清指标出现异常，对临床诊断治疗和预后均有一定的临床实用价值，可将其作为了解肺炎及胸腔积液发展转归的指标。
목적：탐토지원체폐염합병흉강적액환인적혈청여흉강적액염성지표변화정황。방법응용ELISA 쌍항체협심법대흉강적액조（32례）、지원체폐염조（30례）、대조조（35례）등삼조적혈청여흉강적액백개소6（IL-6）、IL-2급종류배사인자α（TNF-α）등염성지표수평진행검측화비교。결과지원체폐염조 IL-6（9．93±1．05）pg／mL，IL-2（4．93±0．55）μg／mL，TNF-α（1．45±0．17）ng／mL，명현고우대조조，이 IL-2칙명현저우대조조，차이균유통계학의의（t ＝6．25、5．88、4．63、5．95、3．69、3．69，균 P ＜0．05）。흉강적액조혈청IL-6、TNF-α수평명현고우지원체폐염조，이 IL-2칙명현저우지원체폐염조，차이균유통계학의의（t ＝4．02、3．06、2．88，균 P ＜0．05）。대량적액환자혈청 IL-6、IL-2급 TNF-α등수평여기타량조차이유통계학의의（균P ＜0．05）。흉강적액조화지원체폐염조흉강적액 IL-6、TNF-α검측수평명현고우대조조，이 IL-2칙명현저우대조조，차이균유통계학의의（t ＝5．69、3．69、6．02、4．11、2．94、3．67，균 P ＜0．05）。흉강적액조흉강적액IL-6、TNF-α수평명현고우지원체폐염조，이 IL-2칙명현저우지원체폐염조，차이균유통계학의의（t ＝3．58、4．13、3．21，균 P ＜0．05）。대량적액환자흉강적액 IL-6、IL-2급 TNF-α수평여기타량조차이유통계학의의（t ＝6．11、5．44、4．82，균 P ＜0．05）。결론IL-6、IL-2급 TNF-α재폐염지원체폐염적발생발전과정중기중요작용，리환지원체폐염합병흉강적액환자흉강적액중 TNF-α、IL-6등염성지표이급환자혈청지표출현이상，대림상진단치료화예후균유일정적림상실용개치，가장기작위료해폐염급흉강적액발전전귀적지표。
Objective To investigate the changes of serum and pleural effusion inflammatory indexes in chil-dren with mycoplasma pneumoniae complicated with pleural effusion.Methods Enzyme linked immunosorbent assay (ELISA)double antibody sandwich method was used in the three of pleural effusion group,mycoplasma pneumonia group,control group and other groups to detect serum and pleural effusion human interleukin 6 (IL -6).human inter-leukin 2 (IL -2)and TNF -(human tumor necrosis factor alpha)etc.Inflammation index levels were detected and compared.Results The group of patients with mycoplasma pneumonia mycoplasma pneumonia patients was (9.93 ± 1.05)pg/mL for the IL -6 level,IL -2 levels for (4.93 ±0.55)μg/mL,(1.45 ±0.17)ng/mL for the TNF alpha level,which were significantly higher than those of the control group,the IL -2 was significantly lower than that of the control group,with statistically significant difference (t =6.25,5.88,4.63,5.95,3.69,5.95,all P <0.05).Compa-ring pleural effusion group and mycoplasma pneumonia group,we found serum IL -6,TNF alpha levels of pleural effu-sion group were significantly higher than that of mycoplasma pneumonia group,while IL -2 was lower than that in group mycoplasma pneumonia,with statistically significant difference (t =4.02,3.06,3.06 and 2.88,all P <0.05). The levels of serum IL -6,IL -2 and TNF -in the serum of patients with different effusion levels were significantly different from the other two groups (all P <0.05).Pleural effusion IL -6 and TNF level of pleural effusion group and mycoplasma pneumonia patients was significantly higher than those of the control group and IL -2 were significantly lower than that of the control group,the difference had statistical significance (t =5.69,3.69,602,4.11,2.94,3.67, all P <0.05).Pleural effusion pleural effusion IL -6 and TNF levels were significantly higher than those in the myco-plasma pneumonia group and IL -2 were significantly lower than that in mycoplasma pneumonia group,the difference had statistical significance (t =3.58,4.13,3.21,all P <0.05).The inflammatory indexes of patients with different effusion volume could be found in the pleural effusion,in patients with a large number of pleural effusion,the IL -2, IL -6 and TNF -levels compared with the other two groups showed significantly different (t =6.11、5.44、4.82,all P <0.05).Conclusion IL -6,IL -2 and TNF alpha in the occurrence and development of mycoplasma pneumoniae pneumonia play an important role.Suffering from mycoplasma pneumonia in patients with pleural effusion,whoseTNF-and IL -6 inflammatory index and serum indexes are abnormal,is of certain clinical practical value for clinical diagnosis,treatment and prognosis,as the indicator of the development and prognosis of pneumonia and pleural effusion.