实用心脑肺血管病杂志
實用心腦肺血管病雜誌
실용심뇌폐혈관병잡지
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
2015年
8期
57-59
,共3页
肺炎%儿童%沙丁胺醇%布地奈德%投药,吸入%疗效比较研究
肺炎%兒童%沙丁胺醇%佈地奈德%投藥,吸入%療效比較研究
폐염%인동%사정알순%포지내덕%투약,흡입%료효비교연구
Pneumonia%Child%Salbutamol%Budesonide%Administration,inhalation%Comparative effectiveness research
目的：比较氧气雾化吸入与超声雾化吸入沙丁胺醇联合布地奈德治疗小儿肺炎的临床疗效。方法选取2013年1月—2014年1月惠州市第一人民医院儿科收治的肺炎患儿80例，随机分为研究组和对照组，每组40例。两组患儿均给予常规治疗，对照组患儿采用沙丁胺醇联合布地奈德超声雾化吸入治疗，研究组患儿采用沙丁胺醇联合布地奈德氧气雾化吸入治疗；两组患儿均治疗7d。比较两组患儿临床疗效、临床症状（咳嗽、肺部啰音、发热）消失时间、住院时间及不良反应发生情况，治疗前后血清肿瘤坏死因子α（ TNF-α）、干扰素γ（ IFN-γ）和白介素4（IL-4）水平。结果研究组患儿临床疗效优于对照组（u=5.380，P<0.05）。研究组患儿咳嗽消失时间、肺部啰音消失时间、发热消失时间及住院时间均短于对照组（ P<0.05）。治疗前两组患儿血清TNF-α、IFN-γ、IL-4水平比较，差异无统计学意义（P>0.05）；治疗后研究组患儿血清TNF-α、IFN-γ、IL-4水平均低于对照组（P<0.05）。研究组患儿不良反应发生率为7.5%，对照组患儿不良反应发生率为2.5%，差异无统计学意义（P>0.05）。结论氧气雾化吸入沙丁胺醇联合布地奈德治疗小儿肺炎的临床疗效优于超声雾化吸入，有利于缩短患儿临床症状消失时间及住院时间，且无严重不良反应。
目的：比較氧氣霧化吸入與超聲霧化吸入沙丁胺醇聯閤佈地奈德治療小兒肺炎的臨床療效。方法選取2013年1月—2014年1月惠州市第一人民醫院兒科收治的肺炎患兒80例，隨機分為研究組和對照組，每組40例。兩組患兒均給予常規治療，對照組患兒採用沙丁胺醇聯閤佈地奈德超聲霧化吸入治療，研究組患兒採用沙丁胺醇聯閤佈地奈德氧氣霧化吸入治療；兩組患兒均治療7d。比較兩組患兒臨床療效、臨床癥狀（咳嗽、肺部啰音、髮熱）消失時間、住院時間及不良反應髮生情況，治療前後血清腫瘤壞死因子α（ TNF-α）、榦擾素γ（ IFN-γ）和白介素4（IL-4）水平。結果研究組患兒臨床療效優于對照組（u=5.380，P<0.05）。研究組患兒咳嗽消失時間、肺部啰音消失時間、髮熱消失時間及住院時間均短于對照組（ P<0.05）。治療前兩組患兒血清TNF-α、IFN-γ、IL-4水平比較，差異無統計學意義（P>0.05）；治療後研究組患兒血清TNF-α、IFN-γ、IL-4水平均低于對照組（P<0.05）。研究組患兒不良反應髮生率為7.5%，對照組患兒不良反應髮生率為2.5%，差異無統計學意義（P>0.05）。結論氧氣霧化吸入沙丁胺醇聯閤佈地奈德治療小兒肺炎的臨床療效優于超聲霧化吸入，有利于縮短患兒臨床癥狀消失時間及住院時間，且無嚴重不良反應。
목적：비교양기무화흡입여초성무화흡입사정알순연합포지내덕치료소인폐염적림상료효。방법선취2013년1월—2014년1월혜주시제일인민의원인과수치적폐염환인80례，수궤분위연구조화대조조，매조40례。량조환인균급여상규치료，대조조환인채용사정알순연합포지내덕초성무화흡입치료，연구조환인채용사정알순연합포지내덕양기무화흡입치료；량조환인균치료7d。비교량조환인림상료효、림상증상（해수、폐부라음、발열）소실시간、주원시간급불량반응발생정황，치료전후혈청종류배사인자α（ TNF-α）、간우소γ（ IFN-γ）화백개소4（IL-4）수평。결과연구조환인림상료효우우대조조（u=5.380，P<0.05）。연구조환인해수소실시간、폐부라음소실시간、발열소실시간급주원시간균단우대조조（ P<0.05）。치료전량조환인혈청TNF-α、IFN-γ、IL-4수평비교，차이무통계학의의（P>0.05）；치료후연구조환인혈청TNF-α、IFN-γ、IL-4수평균저우대조조（P<0.05）。연구조환인불량반응발생솔위7.5%，대조조환인불량반응발생솔위2.5%，차이무통계학의의（P>0.05）。결론양기무화흡입사정알순연합포지내덕치료소인폐염적림상료효우우초성무화흡입，유리우축단환인림상증상소실시간급주원시간，차무엄중불량반응。
Objective To compare the clinical effect on infantile pneumonia between oxygen atomizing inhalation and ultrasound atomizing inhalation of salbutamol combined with budesonide. Methods A total of 80 children with pneumonia were selected in the First People′s Hospital of Huizhou from January 2013 to January 2014 , and they were randomly divided into control group and study group, each of 40 cases. Based on conventional treatment, children of control group were given ultrasound atomizing inhalation of salbutamol combined with budesonide, while children of study group were given oxygen atomizing inhalation of salbutamol combined with budesonide,both groups treated for 7 days. Clinical effect,clinical symptoms ( cough,lung rale,fever) disappeared time,hospital stays,incidence of adverse reactions,serum levels of TNF-α,IFN-γand IL-4 before and after treatment were compared between the two groups. Results The clinical effect of study group was statistically significantly better than that of control group ( u = 5. 380, P < 0. 05 ). Cough disappeared time, lung rale disappeared time,fever disappeared time and hospital stays of study group were statistically significantly shorter than those of control group(P <0. 05). No statistically significant differences of serum levels of TNF -α,IFN -γ or IL-4 was found between the two groups before treatment(P>0. 05),while serum levels of TNF-α,IFN-γ and IL-4 of study group were statistically significantly lower than those of control group after treatment(P<0. 05). The incidence of adverse reactions of study group was 7. 5%, that of control group was 2. 5%, the difference was not statistically significantly different ( P >0. 05 ). Conclusion Oxygen atomizing inhalation of salbutamol combined with budesonide has better clinical effect than ultrasound atomizing inhalation in treating infantile pneumonia,is helpful to shorten the clinical symptoms disappeared time and hospital stays,is without severe adverse reactions.
