实用心脑肺血管病杂志
實用心腦肺血管病雜誌
실용심뇌폐혈관병잡지
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
2015年
8期
28-30
,共3页
脑出血%尼莫地平%神经肽Y%C反应蛋白质
腦齣血%尼莫地平%神經肽Y%C反應蛋白質
뇌출혈%니막지평%신경태Y%C반응단백질
Cerebral hemorrhage%Nimodipine%Neuropeptide Y%C-reactive protein
目的：观察尼莫地平对脑出血患者血浆神经肽Y（ NPY）及超敏C反应蛋白（ hs-CRP）水平的影响。方法选取2012年12月—2014年12月武汉市第一医院收治的脑出血患者90例，按随机数字表法分为观察组和对照组，各45例。对照组患者给予常规治疗，观察组患者在常规治疗基础上联合尼莫地平治疗，两组患者均治疗10 d。比较两组患者治疗前及治疗1 d、5 d、10 d血浆NPY、hs-CRP水平、美国国立卫生研究院卒中量表（ NIHSS）评分及格拉斯哥昏迷量表（ GCS）评分。结果治疗前及治疗1 d、5 d两组患者血浆NPY水平比较，差异无统计学意义（ P>0.05）；治疗10 d观察组患者血浆NPY水平低于对照组（P<0.01）。治疗前及治疗1 d两组患者血浆hs-CRP水平比较，差异无统计学意义（P>0.05）；治疗5 d、10 d观察组患者血浆hs-CRP水平均低于对照组（P<0.01）。治疗前及治疗1 d、5 d两组患者NIHSS评分、GCS评分比较，差异无统计学意义（ P>0.05）；治疗10 d观察组患者NIHSS评分低于对照组，GCS评分高于对照组（P<0.01）。结论尼莫地平能有效降低脑出血患者血浆NPY、hs-CRP水平，减轻神经功能缺损程度。
目的：觀察尼莫地平對腦齣血患者血漿神經肽Y（ NPY）及超敏C反應蛋白（ hs-CRP）水平的影響。方法選取2012年12月—2014年12月武漢市第一醫院收治的腦齣血患者90例，按隨機數字錶法分為觀察組和對照組，各45例。對照組患者給予常規治療，觀察組患者在常規治療基礎上聯閤尼莫地平治療，兩組患者均治療10 d。比較兩組患者治療前及治療1 d、5 d、10 d血漿NPY、hs-CRP水平、美國國立衛生研究院卒中量錶（ NIHSS）評分及格拉斯哥昏迷量錶（ GCS）評分。結果治療前及治療1 d、5 d兩組患者血漿NPY水平比較，差異無統計學意義（ P>0.05）；治療10 d觀察組患者血漿NPY水平低于對照組（P<0.01）。治療前及治療1 d兩組患者血漿hs-CRP水平比較，差異無統計學意義（P>0.05）；治療5 d、10 d觀察組患者血漿hs-CRP水平均低于對照組（P<0.01）。治療前及治療1 d、5 d兩組患者NIHSS評分、GCS評分比較，差異無統計學意義（ P>0.05）；治療10 d觀察組患者NIHSS評分低于對照組，GCS評分高于對照組（P<0.01）。結論尼莫地平能有效降低腦齣血患者血漿NPY、hs-CRP水平，減輕神經功能缺損程度。
목적：관찰니막지평대뇌출혈환자혈장신경태Y（ NPY）급초민C반응단백（ hs-CRP）수평적영향。방법선취2012년12월—2014년12월무한시제일의원수치적뇌출혈환자90례，안수궤수자표법분위관찰조화대조조，각45례。대조조환자급여상규치료，관찰조환자재상규치료기출상연합니막지평치료，량조환자균치료10 d。비교량조환자치료전급치료1 d、5 d、10 d혈장NPY、hs-CRP수평、미국국립위생연구원졸중량표（ NIHSS）평분급격랍사가혼미량표（ GCS）평분。결과치료전급치료1 d、5 d량조환자혈장NPY수평비교，차이무통계학의의（ P>0.05）；치료10 d관찰조환자혈장NPY수평저우대조조（P<0.01）。치료전급치료1 d량조환자혈장hs-CRP수평비교，차이무통계학의의（P>0.05）；치료5 d、10 d관찰조환자혈장hs-CRP수평균저우대조조（P<0.01）。치료전급치료1 d、5 d량조환자NIHSS평분、GCS평분비교，차이무통계학의의（ P>0.05）；치료10 d관찰조환자NIHSS평분저우대조조，GCS평분고우대조조（P<0.01）。결론니막지평능유효강저뇌출혈환자혈장NPY、hs-CRP수평，감경신경공능결손정도。
Objective To observe the impact of nimodipine on plasma nerve peptide Y( NPY) and high-sensitivity C- reactive protein ( hs-CRP ) levels of patients with intracerebral hemorrhage. Methods A total of 90 patients with intracerebral hemorrhage were selected in the First Hospital of Wuhan from December 2012 to December 2014 , and they were randomly divided into control group and observation group,each of 45 cases. Patients of both groups were given conventional treatment,while patients of observation group were given extra nimodipine,both groups treated for 10 days. Plasma NPY and hs-CRP levels,NIHSS score and GCS score before treatment and after 1 day,5 days,10 days of treatment were compared between the two groups. Results No statistically significant differences of plasma NPY level,NIHSS score or GCS score was found between the two groups before treatment or after 1 day,5 days of treatment(P >0. 05),after 10 days of treatment, plasma NPY level and NIHSS score of observation group were statistically significantly lower than those of control group,while GCS score of observation group was statistically significantly higher than that of control group ( P <0. 01 ). No statistically significant differences of plasma hs-CRP level was found between the two groups before treatment or after 1 day of treatment( P>0. 05),while plasma hs-CRP level of observation group was statistically significantly lower than that of control group after 5 days,10 days of treatment, respectively ( P <0. 05 ). Conclusion Nimodipine can effectively control plasma NPY and hs-CRP levels and reduce the severity of nervous functional defects of patients with intracerebral hemorrhage.
