药物不良反应杂志
藥物不良反應雜誌
약물불량반응잡지
Adverse Drug Reactions Journal
2015年
4期
264-267
,共4页
药物相关副作用和不良反应%病案系统,计算机化%全面触发工具
藥物相關副作用和不良反應%病案繫統,計算機化%全麵觸髮工具
약물상관부작용화불량반응%병안계통,계산궤화%전면촉발공구
Drug-related side effects and adverse reactions%Medical records system,computerized%Global trigger tool
目的：探讨全面触发工具（GTT）在我国住院患者药物不良事件（ADE）评估中的应用。方法根据 Institute for Healthcare Improvement Global Trigger Tool for Measuring Adverse Events 及我国具体用药情况，选出14项触发器。自广西医科大学第一附属医院医院信息系统随机抽取2013年1-12月出院病历300份进行审查，筛选触发器阳性病历进行 ADE 判定、分级以及累及器官和系统分析，计算触发器检出率，并与同年度医院 ADE 自愿上报率进行比较。结果300份病历涉及300例患者，其中触发器阳性者59例，占19.67%；共检出触发器阳性72例次（检出1项触发器者48例、2项触发器者9例、3项触发器者2例）。对触发器阳性者进行 ADE 判定，确定 ADE 共64例次，涉及患者49例，ADE 检出率为16.33%（49/300）。64例次 ADE 中53例次（82.81%）为 E 级，6例次（9.38%）为 F 级，5例次（7.81%）为 H 级。损害器官以胃肠系统最多，共21例次，临床表现为呕吐（20例次）和腹泻（1例次）。同年度医院 ADE 自愿上报率为0.43%（286/66395），与经触发器检出的 ADE 发生率16.33%比较，差异有统计学意义（χ2=1479.589，P ﹤0.001）。结论 GTT 可较自愿上报系统发现更多的 ADE。
目的：探討全麵觸髮工具（GTT）在我國住院患者藥物不良事件（ADE）評估中的應用。方法根據 Institute for Healthcare Improvement Global Trigger Tool for Measuring Adverse Events 及我國具體用藥情況，選齣14項觸髮器。自廣西醫科大學第一附屬醫院醫院信息繫統隨機抽取2013年1-12月齣院病歷300份進行審查，篩選觸髮器暘性病歷進行 ADE 判定、分級以及纍及器官和繫統分析，計算觸髮器檢齣率，併與同年度醫院 ADE 自願上報率進行比較。結果300份病歷涉及300例患者，其中觸髮器暘性者59例，佔19.67%；共檢齣觸髮器暘性72例次（檢齣1項觸髮器者48例、2項觸髮器者9例、3項觸髮器者2例）。對觸髮器暘性者進行 ADE 判定，確定 ADE 共64例次，涉及患者49例，ADE 檢齣率為16.33%（49/300）。64例次 ADE 中53例次（82.81%）為 E 級，6例次（9.38%）為 F 級，5例次（7.81%）為 H 級。損害器官以胃腸繫統最多，共21例次，臨床錶現為嘔吐（20例次）和腹瀉（1例次）。同年度醫院 ADE 自願上報率為0.43%（286/66395），與經觸髮器檢齣的 ADE 髮生率16.33%比較，差異有統計學意義（χ2=1479.589，P ﹤0.001）。結論 GTT 可較自願上報繫統髮現更多的 ADE。
목적：탐토전면촉발공구（GTT）재아국주원환자약물불량사건（ADE）평고중적응용。방법근거 Institute for Healthcare Improvement Global Trigger Tool for Measuring Adverse Events 급아국구체용약정황，선출14항촉발기。자엄서의과대학제일부속의원의원신식계통수궤추취2013년1-12월출원병력300빈진행심사，사선촉발기양성병력진행 ADE 판정、분급이급루급기관화계통분석，계산촉발기검출솔，병여동년도의원 ADE 자원상보솔진행비교。결과300빈병력섭급300례환자，기중촉발기양성자59례，점19.67%；공검출촉발기양성72례차（검출1항촉발기자48례、2항촉발기자9례、3항촉발기자2례）。대촉발기양성자진행 ADE 판정，학정 ADE 공64례차，섭급환자49례，ADE 검출솔위16.33%（49/300）。64례차 ADE 중53례차（82.81%）위 E 급，6례차（9.38%）위 F 급，5례차（7.81%）위 H 급。손해기관이위장계통최다，공21례차，림상표현위구토（20례차）화복사（1례차）。동년도의원 ADE 자원상보솔위0.43%（286/66395），여경촉발기검출적 ADE 발생솔16.33%비교，차이유통계학의의（χ2=1479.589，P ﹤0.001）。결론 GTT 가교자원상보계통발현경다적 ADE。
Objective To investigate the use of global trigger tool(GTT)for evaluating adverse drug events( ADE)in hospitalized patients. Methods Fourteen triggers were selected according to Institute for Healthcare Improvement Global Trigger Tool for Measuring Adverse Events and situation of medicine administration in China. Three hundred discharged patientsˊ medical records,coming from hospital information system of the First Affiliated Hospital of Guangxi Medical University from January to December 2013,were selected randomly and examined. The records with positive triggers were filtered and analyzed on estimation and classification of ADE as well as damage of organ and system. The detection rate of triggers was calculated and compared with the voluntary reporting rate of ADE in the same year. Results A total of 300 patients were involved in the 300 records. Of them,there were 59 patients with positive triggers accounting for 19. 67% and 72 cases with positive triggers including 48 patients with only one positive trigger,9 patients with 2 positive triggers,and 2 patients with 3 positive triggers. The cases with positive triggers were analyzed on estimation of ADE. Sixty-four ADEs were confirmed and these ADEs involved 49 patients. The detection rate of ADE was 16. 33%(49 / 300). The 64 ADEs contained 53 ADEs(82. 81% ) of level E,6 ADEs(9. 38% )of level F,and 5 ADEs(7. 81% )of level H. The most common damage of organ was gastrointestinal system and a total of 21 cases developed gastrointestinal damages. The clinical manifestations were vomiting(20 cases)and diarrhea(1 case). The voluntary reporting rate of ADE in the same year was 0. 43%(286 / 66 395),compared with the detection rate of triggers(16. 33% ),the difference was statistically significant( χ2 = 1 479. 589,P ﹤ 0. 001). Conclusion Compared with the voluntary reporting rate,GTT could find more ADE.
