中国基层医药
中國基層醫藥
중국기층의약
Chinese Journal of Primary Medicine and Pharmacy
2015年
19期
2950-2953
,共4页
高血压%血流动力学%右美托咪啶%老年人
高血壓%血流動力學%右美託咪啶%老年人
고혈압%혈류동역학%우미탁미정%노년인
Hypertension%Hemodynamics%Dexmedetomidine%Aged
目的：探讨右美托咪定（DEX）对老年高血压（HBP）患者围麻醉期血压、心率（Heart Rate，HR）及血氧饱和度（SpO2）水平的影响。方法选择接受手术的老年 HT 患者96例，按照随机数字表法分成观察组48例和对照组48例，观察组患者在手术期间持续泵入4μg／mL 的 DEX，而对照组同样方法泵入0．9％氯化钠注射液。在入室后（T0）、输注 DEX 后（T1）、气管插管前（T2）、气管插管后2 min（T3）和气管插管后10 min（T4）分别统计两组患者的心率（HR）、收缩压（SBP）、舒张压（DBP）、脉搏氧饱和度（SpO2），手术结束后统计两组患者自主呼吸恢复时间、呼之睁眼时间和拔管时间，并统计两组患者心血管不良反应。结果两组 T0和 T4时的 HR、SBP、DBP、SpO2比较，差异均无统计学意义（均 P ＞0．05）；T1、T2、T3时，观察组 HR、SBP和 DBP 明显低于对照组（均 P ＜0．05）；两组 T0的 SpO2无明显变化；观察组自主呼吸恢复时间、呼之睁眼时间和拔管时间观察组均显著短于对照组（t ＝8．874、9．073、8．573，均 P ＜0．05）；观察组不良反应率为4．2％，对照组为6．3％，两组差异无统计学意义（χ2＝0．102，均 P ＜0．05）。结论老年 HBP 患者术中泵入 DEX 可以起到明显的镇静作用，且不产生呼吸抑制，可以帮助老年 HBP 患者平稳度过围手术期。
目的：探討右美託咪定（DEX）對老年高血壓（HBP）患者圍痳醉期血壓、心率（Heart Rate，HR）及血氧飽和度（SpO2）水平的影響。方法選擇接受手術的老年 HT 患者96例，按照隨機數字錶法分成觀察組48例和對照組48例，觀察組患者在手術期間持續泵入4μg／mL 的 DEX，而對照組同樣方法泵入0．9％氯化鈉註射液。在入室後（T0）、輸註 DEX 後（T1）、氣管插管前（T2）、氣管插管後2 min（T3）和氣管插管後10 min（T4）分彆統計兩組患者的心率（HR）、收縮壓（SBP）、舒張壓（DBP）、脈搏氧飽和度（SpO2），手術結束後統計兩組患者自主呼吸恢複時間、呼之睜眼時間和拔管時間，併統計兩組患者心血管不良反應。結果兩組 T0和 T4時的 HR、SBP、DBP、SpO2比較，差異均無統計學意義（均 P ＞0．05）；T1、T2、T3時，觀察組 HR、SBP和 DBP 明顯低于對照組（均 P ＜0．05）；兩組 T0的 SpO2無明顯變化；觀察組自主呼吸恢複時間、呼之睜眼時間和拔管時間觀察組均顯著短于對照組（t ＝8．874、9．073、8．573，均 P ＜0．05）；觀察組不良反應率為4．2％，對照組為6．3％，兩組差異無統計學意義（χ2＝0．102，均 P ＜0．05）。結論老年 HBP 患者術中泵入 DEX 可以起到明顯的鎮靜作用，且不產生呼吸抑製，可以幫助老年 HBP 患者平穩度過圍手術期。
목적：탐토우미탁미정（DEX）대노년고혈압（HBP）환자위마취기혈압、심솔（Heart Rate，HR）급혈양포화도（SpO2）수평적영향。방법선택접수수술적노년 HT 환자96례，안조수궤수자표법분성관찰조48례화대조조48례，관찰조환자재수술기간지속빙입4μg／mL 적 DEX，이대조조동양방법빙입0．9％록화납주사액。재입실후（T0）、수주 DEX 후（T1）、기관삽관전（T2）、기관삽관후2 min（T3）화기관삽관후10 min（T4）분별통계량조환자적심솔（HR）、수축압（SBP）、서장압（DBP）、맥박양포화도（SpO2），수술결속후통계량조환자자주호흡회복시간、호지정안시간화발관시간，병통계량조환자심혈관불량반응。결과량조 T0화 T4시적 HR、SBP、DBP、SpO2비교，차이균무통계학의의（균 P ＞0．05）；T1、T2、T3시，관찰조 HR、SBP화 DBP 명현저우대조조（균 P ＜0．05）；량조 T0적 SpO2무명현변화；관찰조자주호흡회복시간、호지정안시간화발관시간관찰조균현저단우대조조（t ＝8．874、9．073、8．573，균 P ＜0．05）；관찰조불량반응솔위4．2％，대조조위6．3％，량조차이무통계학의의（χ2＝0．102，균 P ＜0．05）。결론노년 HBP 환자술중빙입 DEX 가이기도명현적진정작용，차불산생호흡억제，가이방조노년 HBP 환자평은도과위수술기。
Objective To explore the effect of dexmedetomidine(DEX)for blood pressure,heart rate(HR) and SpO2 levels during anesthesia inquiry in elderly hypertensive(HBP)patients.Methods 96 cases with HBP accepted surgery were selected,and were randomly divided into the observation group and the control group,each group in 48 cases,The patients in the observation group continuous pumped into the 4μg/mL of DEX during surgery, while the control group continuous pumped into 0.9% sodium chloride solution during surgery.Heart rate(HR),sys-tolic blood pressure(SBP),diastolic blood pressure(DBP),pulse oxygen saturation(SpO2 )of the two groups after room entrance(T0),after DEX infusion(T1),before intubation(T2),after 2min intubation(T3)and 10 min(T4)after intubation were recorded and compared,extubated time,spontaneous breathing recovery time,call time to eye opening and hospitalization time and the incidence of adverse reactions in two groups were recorded.Results The difference of HR SBP,DBP and SpO2 at T0 and T4 between the two groups was not statistically significant(all P >0.05);HR, SBP and DBP were significantly lower in the observation group than those in the control group at T1,T2,T3(all P <0.05).There were no significant changes of SpO2 in the patientˊs after the room entrance;extubated time,spontaneous breathing recovery time,call time to eye opening and hospitalization time in the observation group were significantly lower than those in the control group(t =8.874,9.073,8.573,all P <0.05).The adverse reactions rate in the observation group was 4.2%,which in the control group was 6.3%,the difference was not statistically significant(P >0.05). Conclusion Continuous pumped DEX has a significant sedative effect in elderly HBP patients during surgery,and does not produce respiratory depression,can help elderly patients with HBP smoothly pass the perioperative period.
