中国基层医药
中國基層醫藥
중국기층의약
Chinese Journal of Primary Medicine and Pharmacy
2015年
19期
2941-2943
,共3页
葡聚糖%真菌感染%实验室诊断
葡聚糖%真菌感染%實驗室診斷
포취당%진균감염%실험실진단
Dextran%Fungal infections%Laboratory diagnosis
目的：探讨（1，3）-β-D葡聚糖检测（G试验）在深部真菌感染临床早期诊断中的应用价值。方法选取住院治疗的深部真菌感染患者86例（观察组），另选志愿参与该次研究的健康者24例作为对照组，对两组研究对象行血浆 G 试验，同时培养可疑感染标本，并将深部真菌感染患者按照培养结果分为阴性组及阳性组，对血浆 G 试验结果进行比较分析。结果对照组血浆 G 试验结果为（6．12±2．87）×10－3 ng／mL，深部真菌感染阴性组、阳性组血浆 G 试验结果分别为（32．58±24．12）×10－3 ng／mL、（101．28±36．04）×10－3 ng／mL，与对照组比较，深部真菌感染阴性组、阳性组血浆 G 试验结果均显著升高，差异均有统计学意义（t ＝18．28、7．92，P ＝0．036、0．042）；同时阳性组血浆 G 试验结果显著高于阴性组，差异有统计学意义（t ＝12．16， P ＝0．038）。血浆 G 试验诊断深部真菌感染阳性率为79．1％，明显高于真菌培养的50．0％，差异有统计学意义（χ2＝31．26，P ＝0．002）。结论在深部真菌感染的早期临床诊断中，血浆 G 试验检测阳性率较高，优于真菌培养，值得临床中广泛应用。
目的：探討（1，3）-β-D葡聚糖檢測（G試驗）在深部真菌感染臨床早期診斷中的應用價值。方法選取住院治療的深部真菌感染患者86例（觀察組），另選誌願參與該次研究的健康者24例作為對照組，對兩組研究對象行血漿 G 試驗，同時培養可疑感染標本，併將深部真菌感染患者按照培養結果分為陰性組及暘性組，對血漿 G 試驗結果進行比較分析。結果對照組血漿 G 試驗結果為（6．12±2．87）×10－3 ng／mL，深部真菌感染陰性組、暘性組血漿 G 試驗結果分彆為（32．58±24．12）×10－3 ng／mL、（101．28±36．04）×10－3 ng／mL，與對照組比較，深部真菌感染陰性組、暘性組血漿 G 試驗結果均顯著升高，差異均有統計學意義（t ＝18．28、7．92，P ＝0．036、0．042）；同時暘性組血漿 G 試驗結果顯著高于陰性組，差異有統計學意義（t ＝12．16， P ＝0．038）。血漿 G 試驗診斷深部真菌感染暘性率為79．1％，明顯高于真菌培養的50．0％，差異有統計學意義（χ2＝31．26，P ＝0．002）。結論在深部真菌感染的早期臨床診斷中，血漿 G 試驗檢測暘性率較高，優于真菌培養，值得臨床中廣汎應用。
목적：탐토（1，3）-β-D포취당검측（G시험）재심부진균감염림상조기진단중적응용개치。방법선취주원치료적심부진균감염환자86례（관찰조），령선지원삼여해차연구적건강자24례작위대조조，대량조연구대상행혈장 G 시험，동시배양가의감염표본，병장심부진균감염환자안조배양결과분위음성조급양성조，대혈장 G 시험결과진행비교분석。결과대조조혈장 G 시험결과위（6．12±2．87）×10－3 ng／mL，심부진균감염음성조、양성조혈장 G 시험결과분별위（32．58±24．12）×10－3 ng／mL、（101．28±36．04）×10－3 ng／mL，여대조조비교，심부진균감염음성조、양성조혈장 G 시험결과균현저승고，차이균유통계학의의（t ＝18．28、7．92，P ＝0．036、0．042）；동시양성조혈장 G 시험결과현저고우음성조，차이유통계학의의（t ＝12．16， P ＝0．038）。혈장 G 시험진단심부진균감염양성솔위79．1％，명현고우진균배양적50．0％，차이유통계학의의（χ2＝31．26，P ＝0．002）。결론재심부진균감염적조기림상진단중，혈장 G 시험검측양성솔교고，우우진균배양，치득림상중엄범응용。
Objective To discuss the detection value of(1,3)-β-D -glucan in the early diagnosis of fun-gal infection in clinic.Methods 86 patients with deep fungal infection were selected as the study group,and 24 cases of healthy volunteers were selected as the control group,all groups took plasma G test,while cultivating specimens sus-pected infection and deep fungal infections in patients were divided according to culture -negative group and positive group,plasma G test results were compared.Results In the control group,G test was (6.12 ±2.87)×10 -3 ng/mL in plasma,deep fungal infection negative,positive test results were (32.58 ±24.12)×10 -3 ng/mL and (101.28 ± 36.04)×10 -3 ng/mL in plasma G respectively,positive group G results in plasma were significantly increased,the differences were statistically significant(t =18.28,7.92,P =0.036,0.042);both positive plasma G test results were significantly higher than that of the negative group,the difference was statistically significant(t =12.16,P =0.038). Plasma G test positive diagnosis of deep fungal infection was 79.1%,significantly better than the fungal culture 50.0%,the difference was statistically significant(χ2 =31.26,P =0.002).Conclusion In early clinical diagnosis of deep true infection,plasma G test positive rate is higher than fungal culture,and is worthy of wider application.
