中华生物医学工程杂志
中華生物醫學工程雜誌
중화생물의학공정잡지
Chinese Journal of Biomedical Engineering
2015年
4期
358-361
,共4页
肠易激综合征%功能性消化不良%情绪障碍%脑肠肽%细胞因子
腸易激綜閤徵%功能性消化不良%情緒障礙%腦腸肽%細胞因子
장역격종합정%공능성소화불량%정서장애%뇌장태%세포인자
Irritable bowel syndrome%Functional dyspepsia%Emotional disorder%ghrelin%Cell factor
目的：探讨肠易激综合征（IBS）重叠功能性消化不良（FD）患者情绪障碍及其与脑肠肽、细胞因子水平关系。方法选取2010年6月至2013年6月本院消化科收治的64例IBS重叠FD患者作为研究对象，采用焦虑调查表（SAS）、抑郁调查表（SDS）调查患者负面情绪，比较患者的内皮素、生长抑素（SS）、5?羟色胺以及血管活性肠肽（VIP）等水平。结果病例组患者SAS、SDS评分均高于对照组，差异有统计学意义（P<0.05）；单因素分析结果显示，情绪障碍组和无情绪障碍组患者在病程、婚姻方面及IL?10、VIP、SS、5?羟色胺水平与对照组比较差异均有统计学意义（P<0.05）；且VIP水平显著低于无情绪障碍组患者；病程<1年患者IL?10、5?羟色胺水平均高于1~5年、>5年患者（P<0.05）；>5年患者内皮素、VIP水平均高于<1年、1~5年患者（P<0.05）。结论 IBS重叠FD患者焦虑、抑郁水平处于轻度范畴，可能与病程和婚姻状态有关，患者消化道症状可能与内皮素、SS、VIP水平有密切关系。
目的：探討腸易激綜閤徵（IBS）重疊功能性消化不良（FD）患者情緒障礙及其與腦腸肽、細胞因子水平關繫。方法選取2010年6月至2013年6月本院消化科收治的64例IBS重疊FD患者作為研究對象，採用焦慮調查錶（SAS）、抑鬱調查錶（SDS）調查患者負麵情緒，比較患者的內皮素、生長抑素（SS）、5?羥色胺以及血管活性腸肽（VIP）等水平。結果病例組患者SAS、SDS評分均高于對照組，差異有統計學意義（P<0.05）；單因素分析結果顯示，情緒障礙組和無情緒障礙組患者在病程、婚姻方麵及IL?10、VIP、SS、5?羥色胺水平與對照組比較差異均有統計學意義（P<0.05）；且VIP水平顯著低于無情緒障礙組患者；病程<1年患者IL?10、5?羥色胺水平均高于1~5年、>5年患者（P<0.05）；>5年患者內皮素、VIP水平均高于<1年、1~5年患者（P<0.05）。結論 IBS重疊FD患者焦慮、抑鬱水平處于輕度範疇，可能與病程和婚姻狀態有關，患者消化道癥狀可能與內皮素、SS、VIP水平有密切關繫。
목적：탐토장역격종합정（IBS）중첩공능성소화불량（FD）환자정서장애급기여뇌장태、세포인자수평관계。방법선취2010년6월지2013년6월본원소화과수치적64례IBS중첩FD환자작위연구대상，채용초필조사표（SAS）、억욱조사표（SDS）조사환자부면정서，비교환자적내피소、생장억소（SS）、5?간색알이급혈관활성장태（VIP）등수평。결과병례조환자SAS、SDS평분균고우대조조，차이유통계학의의（P<0.05）；단인소분석결과현시，정서장애조화무정서장애조환자재병정、혼인방면급IL?10、VIP、SS、5?간색알수평여대조조비교차이균유통계학의의（P<0.05）；차VIP수평현저저우무정서장애조환자；병정<1년환자IL?10、5?간색알수평균고우1~5년、>5년환자（P<0.05）；>5년환자내피소、VIP수평균고우<1년、1~5년환자（P<0.05）。결론 IBS중첩FD환자초필、억욱수평처우경도범주，가능여병정화혼인상태유관，환자소화도증상가능여내피소、SS、VIP수평유밀절관계。
Objective To investigate the mood disorder in patients with irritable bowel syndrome (IBS)overlapped with functional dyspepsia(FD)and its relationship with ghrelin and cytokine levels in the patients. Methods The study subjects were 64 patients with FD?overlapped IBS treated in our Department of Gastroenterology between June 2010 and June 2013. Self?Rating Anxiety Scale(SAS)and Self?Rating Depression Scale (SDS) were used to measure the negative emotions in these patients. The levels of endothelin,somatostatin (SS),5?serotonin and vasoactive intestinal peptide (VIP) in the patients were investigated and compared. Results Compared with the control group,patients with FD?overlapped IBS had higher scores by SAS and SDS,with statistically significant difference (P<0.05). Univariate analysis indicated that,compared with controls,patients with or without mood disorders showed statistical differences in duration of disease,marital status,and levels of IL?10,VIP,SS and 5?serotonin(P<0.05);VIP level was significantly lower in patients with than those without mood disorder. Patients with <1 year duration of disease had higher IL?10 and 5?serotonin levels compared to those with disease duration between 1 and 5 years,and much higher IL?10 and 5?serotonin levels compared to those with>5 years duration of disease(P<0.05). Patients with>5 years duration of disease had higher endothelin and VIP levels compared to those with duration of disease<1 year or between 1 and 5 years(P<0.05). Conclusion FD?overlapped IBS patients have mild range of anxiety and depression which may be related to the disease duration and marital status. The gastrointestinal symptoms in these patients may be closely associated with endothelin,SS and VIP levels.
