CAJ | 학술논문

目的：使用光学相干断层扫描（OCT）观察妊娠高血压综合征（PIHS）患者的眼底改变，探讨眼底改变分期与PIHS分级的关系。方法收集2011年12月至2014年12月本院就诊的PIHS患者132例（264眼），所有患者进行视力、验光、裂隙灯检查、眼底检查和OCT检查。分析眼底改变分期与PIHS严重程度分级的相关性，随访6个月观察OCT表现的恢复情况。结果随着PIHS病情的加重，眼底病变也逐渐加重，眼底改变分期与PIHS分级呈正相关（C=0.439、χ2=152.87，P=0.000）。OCT检查显示有异常172眼，其中视网膜神经上皮层浆液性脱离94眼，色素上皮层及光感受器内、外节交界面改变40眼，视盘水肿及视网膜出血等改变38眼。随访6个月OCT观察142眼恢复正常，其中随访1个月恢复正常102眼，2个月恢复正常38眼，3~5个月恢复正常2眼，6个月后有30眼症状虽明显好转，但未恢复正常。结论 OCT在PIHS的诊断及评估方面较其他检查方法具有明显优势。
목적：사용광학상간단층소묘（OCT）관찰임신고혈압종합정（PIHS）환자적안저개변，탐토안저개변분기여PIHS분급적관계。방법수집2011년12월지2014년12월본원취진적PIHS환자132례（264안），소유환자진행시력、험광、렬극등검사、안저검사화OCT검사。분석안저개변분기여PIHS엄중정도분급적상관성，수방6개월관찰OCT표현적회복정황。결과수착PIHS병정적가중，안저병변야축점가중，안저개변분기여PIHS분급정정상관（C=0.439、χ2=152.87，P=0.000）。OCT검사현시유이상172안，기중시망막신경상피층장액성탈리94안，색소상피층급광감수기내、외절교계면개변40안，시반수종급시망막출혈등개변38안。수방6개월OCT관찰142안회복정상，기중수방1개월회복정상102안，2개월회복정상38안，3~5개월회복정상2안，6개월후유30안증상수명현호전，단미회복정상。결론 OCT재PIHS적진단급평고방면교기타검사방법구유명현우세。
Objective To investigate the ocular fundus changes in patients with pregnancy induced hypertension syndrome (PIHS) by using optical coherence tomography (OCT), and to explore the relationship between ocular fundus staging and PIHS grading. Methods A total of 132 PIHS patients(264 eyes) in our hospital between December 2011 and December 2014 were included in this study. All the patients underwent optometry for visual acuity and refraction, slit lamp examination, ocular fundus examination and OCT. Correlation between staging of fundus changes and grading of the PIHS severity was analyzed. OCT findings were followed up for 6 months during the recovery. Results Retinopathy gradually worsened along with the progression of PIHS,and the staging of fundus changes was positively correlated with the grading of PIHS (C=0.439,χ2=152.87, P=0.000). OCT showed abnormality in 172 eyes, with neurosensory serous retinal detachment in 94,disorders of pigment epithelium and photoreceptor inner/outer segment interface in 40,optic disc edema and retinal bleeding in 38. At 6 months of follow?up,142 eyes had become normal,including 102 which recovered within one month,38 within 2 months,and 2 within 3 to 5 months. At 6 months,30 eyes experienced significant improvement in symptoms,but were not fully recovered. Conclusion OCT shows obvious advantages over other examination modalities in diagnosis and assessment of PIHS.