CAJ | 학술논문

线粒体是机体能量代谢与细胞信号转过程中关键的细胞器，在多种信号传导、调节Ca2+稳态和介导细胞凋亡等过程中均发挥着重要的作用。线粒体功能障碍与扩张型心肌病、缺血再灌注损伤和心力衰竭等心血管疾病的发生发展密切相关。本文围绕缺血再灌注损伤机制与线粒体结构和功能障碍的关系做一简要综述。
선립체시궤체능량대사여세포신호전과정중관건적세포기，재다충신호전도、조절Ca2+은태화개도세포조망등과정중균발휘착중요적작용。선립체공능장애여확장형심기병、결혈재관주손상화심력쇠갈등심혈관질병적발생발전밀절상관。본문위요결혈재관주손상궤제여선립체결구화공능장애적관계주일간요종술。
Mitochondria are critical organelles of energy metabolism in organism and play a pivotal role in , cell signaling process , such as signal transduction , Ca2+ homeostasis , and apoptotic regulation and other processes.More and more studies show that the development of the dila-ted cardiomyopathy , ischemia-reperfusion injury , the heart failure and other cardiovascular diseases , all of which are also closely related to the mitochondrial dysfunction .This review focuses on the relationship be-tween ischemia -reperfusion injury mechanisms and mitochondrial dys-function to make a brief overview .