CAJ | 학술논문

胆道闭锁是发生于出生3个月内婴幼儿的疾病，其特征为肝内外胆管纤维化闭锁。尽管肝门空肠吻合术能部分缓解症状，但仍有80%左右的患儿需行肝移植治疗。目前关于胆道闭锁的病因及发病机制并未完全阐明，现主要研究集中于分子生物学因素、胚胎学因素、病毒感染/免疫应答因素。
담도폐쇄시발생우출생3개월내영유인적질병，기특정위간내외담관섬유화폐쇄。진관간문공장문합술능부분완해증상，단잉유80%좌우적환인수행간이식치료。목전관우담도폐쇄적병인급발병궤제병미완전천명，현주요연구집중우분자생물학인소、배태학인소、병독감염/면역응답인소。
Biliary atresia ( BA) is a pediatric liver disease characterized by progressive inflammation and fi-brosis of both the extrahepatic and intrahepatic bile ducts. Even though Kasai portoenterostomy increases the survival of children with BA, 80% of patients with BA will eventually require liver transplantation, making this condition the leading indication for pediatric liver transplantation worldwide. Currently,the causes of this disease are largely unde-fined and theories of pathogenesis include viral infection,autoimmune-mediated bile duct destruction,and abnormalities in bile duct development.