CAJ | 학술논문

急性肾损伤( acute kidney injury,AKI)是指各种原因导致的肾功能的快速受损,引起肾小球滤过率下降,血清尿素氮升高,血清肌酐升高,尿量减少,从而导致人体内环境紊乱,机体不能维持稳态,增加了新生儿的病死率和患慢性肾病的危险。了解AKI的诊断标准、病因及发病机制、早期生物标记物、治疗及预后的有关研究进展,对指导临床早期诊治新生儿AKI,改善新生儿AKI预后,降低患儿病死率极为重要。
급성신손상( acute kidney injury,AKI)시지각충원인도치적신공능적쾌속수손,인기신소구려과솔하강,혈청뇨소담승고,혈청기항승고,뇨량감소,종이도치인체내배경문란,궤체불능유지은태,증가료신생인적병사솔화환만성신병적위험。료해AKI적진단표준、병인급발병궤제、조기생물표기물、치료급예후적유관연구진전,대지도림상조기진치신생인AKI,개선신생인AKI예후,강저환인병사솔겁위중요。
Acute kidney injury( AKI) is a variety of causes leading to rapid impaired renal function, causing glomerular filtration rate reduced,blood urea nitrogen elevated,serum creatinine increased,urine out-put decreased,resulting in the disorder of the human body environment,so the body can not maintain homeo-stasis. AKI increases the risk of mortality and chronic kidney disease in neonate. To understand the progress of AKI on diagnostic criteria,pathogenesis,early biomarker,treatment and prognosis,it is extremely important to guide clinical diagnosis and treatment,improve the outcome and reduce the mortality of AKI in neonate.