CAJ | 학술논문

目的：通过检测黏附分子 E-选择素在胃癌中的表达，进一步探讨 E-选择素与胃癌淋巴转移及远处转移之间的关系。方法选取2011年6月至2013年6月在吉林大学中日联谊医院行胃癌根治术的患者，从中随机选取53例经术后病理诊断为腹膜转移者作为病例组；随机选取50例术前常规检查、手术过程中的探查均未发现明确腹膜转移者作为对照组，对 E-选择素的表达情况与临床病理参数之间的关系进行分析。结果腹膜转移组中 E-选择素阳性率为86．8％，对照组中 E-选择素阳性率为18.0％。E-选择素阳性表达主要在血管内皮细胞的胞浆上，此外肿瘤细胞胞膜上亦可见 E-选择素的表达。结论E-选择素在胃癌大网膜转移灶中的毛细血管内皮细胞上有表达，且随着病变的进展也呈现出一个逐渐上升的趋势，所以 E-选择素很可能是胃癌腹膜转移的一个重要的分子生物学标志物。
목적：통과검측점부분자 E-선택소재위암중적표체，진일보탐토 E-선택소여위암림파전이급원처전이지간적관계。방법선취2011년6월지2013년6월재길림대학중일련의의원행위암근치술적환자，종중수궤선취53례경술후병리진단위복막전이자작위병례조；수궤선취50례술전상규검사、수술과정중적탐사균미발현명학복막전이자작위대조조，대 E-선택소적표체정황여림상병리삼수지간적관계진행분석。결과복막전이조중 E-선택소양성솔위86．8％，대조조중 E-선택소양성솔위18.0％。E-선택소양성표체주요재혈관내피세포적포장상，차외종류세포포막상역가견 E-선택소적표체。결론E-선택소재위암대망막전이조중적모세혈관내피세포상유표체，차수착병변적진전야정현출일개축점상승적추세，소이 E-선택소흔가능시위암복막전이적일개중요적분자생물학표지물。
Objective To test the expression level of adhesion molecule E-selectin in gastric cancer and then investi-gate the association between E-selectin and lymph node metastasis and distant metastasis of gastric cancer.Methods We chose patients who underwent radical gastrectomy from June 2011 to June 2013 in the China-Japan Union Hospital of Jilin University,from which 53 cases who were diagnosed with peritoneal metastasis through postoperative patholo-gy and 50 cases who were found with no definite peritoneal metastasis through preoperative routine inspections and in-traoperative exploration were randomly selected as peritoneal metastasis group and control group,respectively.Then we analyzed the association between E-selectin expression and clinical pathologic parameters.Results The E-selectin positive rate of peritoneal metastasis group and control group is 86.8% and 18.0%,respectively.E-selectin is mainly expressed on the cytoplasm of vascular endothelial cells and can be seen on the cell membrane of tumor cells.Conclusion Since E-selectin is expressed on the cytoplasm of vascular endothelial cells in gastric cancer omentum metastatic le-sions and the level is increasing with the progress of gastric cancer,it is probably a molecular biomarker for peritoneal metastasis in gastric cancer.